Collagen typing of granulation tissue induced by chitin and chitosan
Collagen typing of granulation tissue induced by chitin and chitosan
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DOI：
10.1016/s0144-8617(98)00055-1
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发表时间：
1998-10-01
影响因子：
11.2
通讯作者：
Minami, S
中科院分区：
文献类型：
--
作者：
Kojima, K;Okamoto, Y;Minami, S
采用宏观和微观观察方法，评价了几丁质或壳聚糖包覆聚酯非织造布（chitin-NWF、壳聚糖-NWF）和未包覆聚酯非织造布（对照）植入猫腹壁后对肉芽组织的影响。种植体周围的组织生长以壳聚糖- nwf最明显，而甲壳素- nwf最少。壳聚糖- nwf组的炎症反应更强烈。在植入物周围的组织中，与其他nwf相比，几丁质nwf诱导了许多巨细胞和显著的血管生成。与其他种植体相比，甲壳素- nwf种植体中I、III和IV型胶原的合成水平较高，尤其是IV型胶原。植入后第14天，几丁质nwf周围组织中III型和IV型胶原水平也较高。壳聚糖- nwf在周围组织中诱导的每种胶原蛋白的合成模式与对照组非常相似。1998爱思唯尔科学有限公司版权所有。
Granulation tissue induced by chitin- or chitosan-coated polyester nonwoven fabric (chitin-NWF, chitosan-NWF) and uncoated NWF (control) implanted in the feline abdominal wall was evaluated by macroscopic and microscopic observation. Tissue growth around the implant was most marked with chitosan-NWF and least with chitin-NWF. The inflammatory reaction was much stronger with chitosan-NWF. In the tissue surrounding the implant, many giant cells and prominent angiogenesis were induced by chitin-NWF compared to the other NWFs. Types I, III and IV collagen were synthesized at higher levels in the chitin-NWF implants, especially type IV collagen, compared with the other implants. At 14 days after implantation, the levels of types III and IV collagen were also greater in the tissue surrounding the chitin-NWF. The pattern of synthesis of each type of collagen induced by chitosan-NWF in the surrounding tissue closely resembled that of the control. (C) 1998 Elsevier Science Ltd. All rights reserved.