Maternal obesity reduces placental autophagy marker expression in uncomplicated pregnancies
Maternal obesity reduces placental autophagy marker expression in uncomplicated pregnancies
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DOI：
10.1111/jog.14315
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发表时间：
2020-05-28
影响因子：
1.6
通讯作者：
Eastabrook, Genevieve
中科院分区：
文献类型：
--
作者：
Cohen, Matthew;Guo, Emily;Eastabrook, Genevieve
目的肥胖与自噬的改变有关，其在孕妇中的发病率增加与胎盘介导的妊娠并发症(如先兆子痫和宫内生长受限)的发生率有关。自噬与正常的胎盘形成有关，因此自噬的改变可能导致胎盘功能和发育受损。方法对肥胖(BMI=30 kg/m(2))和正常体重(BMI)的胎盘和大网膜标本进行免疫组织化学和免疫印迹分析
Aim Obesity has been associated with changes in autophagy and its increasing prevalence among pregnant women is implicated in higher rates of placental-mediated complications of pregnancy such as pre-eclampsia and intrauterine growth restriction. Autophagy is involved in normal placentation, thus changes in autophagy may lead to impaired placental function and development. The aim of this study was to investigate the connection between obesity and autophagy in the placenta in otherwise uncomplicated pregnancies.Methods Immunohistochemistry and western blot analysis were done on placental and omental samples from obese (body mass index [BMI] >= 30 kg/m(2)) and normal weight (BMI