Influence of supersaturation and structurally related additives on the crystal growth of α-lactose monohydrate
Influence of supersaturation and structurally related additives on the crystal growth of α-lactose monohydrate
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DOI：
10.1016/s0022-0248(01)01608-6
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发表时间：
2002-01-01
影响因子：
1.8
通讯作者：
Coquerel, G
中科院分区：
文献类型：
--
作者：
Garnier, S;Petit, S;Coquerel, G
结果表明，在室温下在水中的标题化合物的晶体生长过程中，增加过饱和度诱导平均晶体尺寸的重要增加，这可以通过考虑溶剂的作用和作为结晶介质中的大规模杂质的f-乳糖端基异构体的作用来解释。在测试的六种结构相关的添加剂中，其中四种由于其各向异性吸附能力而导致显著的形态变化。取决于添加剂的性质，晶体习性从沿B轴沿着“伸长”或沿a轴沿着“扁平”变化。这些数据可以合理化的3D氢键网络的仔细分析，并通过使用分子建模的吸附机制的模拟，假设吸附能力和解吸的难度直接依赖于保存的分子间氢键的比例。(C)2002 Elsevier Science B. V.保留所有权利。
It is shown that increasing the supersaturation during crystal growth of the title compound in water at room temperature induces an important increase in the mean crystal size, which can be explained by taking into account the role of the solvent and that of the fi-lactose anomer acting as large scale impurities in the crystallizing medium. Among the six structurally related additives tested, four of them lead to significant morphological changes, due to their anisotropic adsorption abilities. Depending on the nature of the additive, crystal habit varies from "elongated" along the b direction or "flattened" along the a axis. These data could be rationalized by a careful analysis of the 3D hydrogen bond network and by using molecular modelling for the simulation of the adsorption mechanisms, assuming that adsorption ability and desorption difficulty were directly dependent on the proportion of preserved intermolecular hydrogen bonds. (C) 2002 Elsevier Science B.V. All rights reserved.