MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T
MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T
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在 3T 和 7T 临床平台上以超短回波时间增强信号强度的人脑 MR 波谱
DOI：
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发表时间：
2009
影响因子：
3.3
通讯作者：
R. Gruetter
中科院分区：
文献类型：
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作者：
R. Mekle;V. Mlynárik;G. Gambarota;M. Hergt;G. Krueger;R. Gruetter
最近，提出了自旋回波全强度获得局部（SPECIAL）光谱技术，以将毫秒（ms）量级的短TE与全灵敏度的优势结合起来，并应用于体内大鼠大脑。在本研究中，通过结合交错水抑制（WS）和外容积饱和（OVS）、优化序列时序和使用FASTMAP改进匀场，对SPECIAL进行了调整和优化，以在3 T和7 T的临床平台上使用。在临床3 T和7 T系统上，以低于或等于6 ms的TE采集了6名志愿者的高质量人脑单体素光谱。窄线宽（对于水，3 T下为6.6 ± 0.6 Hz，7 T下为12.1 ± 1.0 Hz）和无伪影光谱的高信噪比（SNR）使得能够定量由18种代谢物组成的神经化学谱，在两种场强下Cramér-Rao下限（CRLB）均低于20%。与3 T相比，7 T下灵敏度增强，光谱分辨率提高，扫描时间缩短两倍，12种代谢物的定量精度提高，CRLB低于20%的乳酸盐的额外定量。每单位时间的平均SNR（=峰高/噪声均方根[RMS]）增加1.7倍，也证明了7 T下灵敏度的提高。Magn Reson Med，2009年。© 2009 Wiley利斯公司
Recently, the spin‐echo full‐intensity acquired localized (SPECIAL) spectroscopy technique was proposed to unite the advantages of short TEs on the order of milliseconds (ms) with full sensitivity and applied to in vivo rat brain. In the present study, SPECIAL was adapted and optimized for use on a clinical platform at 3T and 7T by combining interleaved water suppression (WS) and outer volume saturation (OVS), optimized sequence timing, and improved shimming using FASTMAP. High‐quality single voxel spectra of human brain were acquired at TEs below or equal to 6 ms on a clinical 3T and 7T system for six volunteers. Narrow linewidths (6.6 ± 0.6 Hz at 3T and 12.1 ± 1.0 Hz at 7T for water) and the high signal‐to‐noise ratio (SNR) of the artifact‐free spectra enabled the quantification of a neurochemical profile consisting of 18 metabolites with Cramér‐Rao lower bounds (CRLBs) below 20% at both field strengths. The enhanced sensitivity and increased spectral resolution at 7T compared to 3T allowed a two‐fold reduction in scan time, an increased precision of quantification for 12 metabolites, and the additional quantification of lactate with CRLB below 20%. Improved sensitivity at 7T was also demonstrated by a 1.7‐fold increase in average SNR (= peak height/root mean square [RMS]‐of‐noise) per unit‐time. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
使用受激回波进行局部成像。
影响因子：
3.3
作者：
Mills,P;Chew,W;Litt,L;Moseley,M
通讯作者：
Moseley,M
影响因子：
2.2
作者：
Gruetter, R;Weisdorf, SA;Ugurbil, K
通讯作者：
Ugurbil, K