Associations between multipollutant day types and select cardiorespiratory outcomes in Columbia, South Carolina, 2002 to 2013.
Associations between multipollutant day types and select cardiorespiratory outcomes in Columbia, South Carolina, 2002 to 2013.
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2002 年至 2013 年南卡罗来纳州哥伦比亚市多污染物日类型与特定心肺结果之间的关联。
DOI：
10.1097/ee9.0000000000000030
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Vena,John
中科院分区：
文献类型：
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作者：
Pearce,JohnL;Neelon,Brian;Bozigar,Matthew;Hunt,KellyJ;Commodore,Adwoa;Vena,John
背景：空气污染的健康研究越来越多地旨在研究空气污染物混合物与健康之间的关联。目的：估计2002年至2013年期间在南卡罗来纳州的哥伦比亚观察到的环境空气污染物组合与选择的心肺结果之间的关联。首先，我们通过将自组织映射应用于二氧化氮（NO 2），二氧化硫（SO 2），臭氧（O 3）和颗粒物≤ 2.5 μm（PM 2.5）的日常测量，确定了一组观测到的污染物组合，我们将其定义为多污染物日类型（MDT）。然后，过度分散的泊松时间序列模型被用来估计MDT和每个结果之间的关联，使用一个“干净”的MDT指涉和控制长期，季节性和一周中的一天的趋势和气象。结果包括哮喘和上呼吸道感染（URI）和充血性心力衰竭（CHF）和缺血性心脏病（IHD）的住院治疗的每日急诊室访问。结果：我们发现，一些MDT显着和正相关（点估计值范围为102%至5%）与心肺功能的结果相比，在哥伦比亚天低污染。估计的相关性显示，在温暖干燥的日子里，哮喘，URI和IHD的结果增加了2-4%，经历了O3和PM2.5水平的升高。我们还发现，凉爽的日子与更高的NO 2污染与哮喘，CHF和IHD的结果增加（2-5%）。结论：我们的分析继续支持使用自组织地图开发多污染物暴露指标，并进一步说明如何将这些指标应用于探索相关污染物组合和健康之间的关联。
Background:Health studies of air pollution are increasingly aiming to study associations between air pollutant mixtures and health.Objective:Estimate associations between observed combinations of ambient air pollutants and select cardiorespiratory outcomes in Columbia, South Carolina, during 2002 to 2013.Methods:We estimate associations using a two-stage approach. First, we identified a collection of observed pollutant combinations, which we define as multipollutant day types (MDTs), by applying a self-organizing map to daily measures of nitrogen dioxide (NO 2), sulfur dioxide (SO 2), ozone (O 3), and particulate matter≤ 2.5 μm (PM 2.5). Then, overdispersed Poisson time-series models were used to estimate associations between MDTs and each outcome using a “clean” MDT referent and controlling for long-term, seasonal, and day-of-the-week trends and meteorology. Outcomes included daily emergency department visits for asthma and upper respiratory infection (URI) and hospital admissions for congestive heart failure (CHF) and ischemic heart disease (IHD).Results:We found that a number of MDTs were significantly and positively associated (point estimates ranged from≈ 2% to 5%) with cardiorespiratory outcomes in Columbia when compared to days with low pollution. Estimated associations revealed that outcomes for asthma, URIs, and IHD increased 2–4% on warm, dry days experiencing elevated levels of O 3 and PM 2.5. We also found that cooler days with higher NO 2 pollution associated with increased asthma, CHF, and IHD outcomes (2–5%).Conclusion:Our analysis continues support for using self-organizing maps to develop multipollutant exposure metrics and further illustrates how such metrics can be applied to explore associations between pertinent pollutant combinations and health.