Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients
Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients
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DOI：
10.1016/j.jpsychires.2008.01.014
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发表时间：
2008-11-01
影响因子：
4.8
通讯作者：
Balottin, Umberto
中科院分区：
文献类型：
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作者：
Ferrari, Marco;Termine, Cristiano;Balottin, Umberto
抽动秽语综合征（TS）是一种神经精神疾病，其中多巴胺能功能障碍和免疫系统异常似乎共存。采用实时荧光定量PCR技术，我们测定了15名TS患者和15名性别和年龄匹配的健康对照者（HC）外周血淋巴细胞（PBL）中多巴胺受体（DR）D1-5的mRNA表达。TS细胞中DR 135 mRNA水平高于HC细胞。TS强迫症患者外周血DRD 5 mRNA水平与强迫症状严重程度呈高度正相关。TS患者外周血淋巴细胞中DRD 5 mRNA的上调可能代表多巴胺能功能障碍的外周标志物，并支持TS中免疫系统的参与。(C)2008爱思唯尔有限公司保留所有权利。
Tourette syndrome (TS) is a neuropsychiatric disorder in which dopaminergic dysfunction and immune system abnormalities seem to coexist. Using real-time PCR, we determined mRNA expression of dopamine receptors (DRs) D1-5 in peripheral blood lymphocytes (PBLs) from 15 TS patients and 15 sex- and age-matched healthy controls (HCs). DR135 mRNA levels in cells from TS were higher than in cells from HCs. In TS patients with obsessive-compulsive disorder, DRD5 mRNA levels in PBLs showed a highly positive correlation with the severity of compulsive symptoms. DRD5 mRNA upregulation in PBLs from TS patients may represent a peripheral marker of dopaminergic dysfunction and supports the involvement of the immune system in TS. (C) 2008 Elsevier Ltd. All rights reserved.