Prospective Study of Alcohol Use and Hearing Loss in Men
Prospective Study of Alcohol Use and Hearing Loss in Men
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DOI：
10.1097/aud.0b013e3181f46a2f
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发表时间：
2011-02-01
期刊：
影响因子：
3.7
通讯作者：
Curhan, Gary C.
中科院分区：
文献类型：
--
作者：
Curhan, Sharon G.;Eavey, Roland;Curhan, Gary C.
目的：听力损失是一种常见的致残性感觉障碍，但关于潜在可改变的危险因素的前瞻性数据有限。以前的研究表明，饮酒可能会影响听力损失的发展，但结果并不一致。本研究的目的是前瞻性地研究酒精使用和听力损失之间的关系，在man.Design：我们前瞻性地研究酒精摄入量和自我报告的专业诊断的听力损失之间的独立关联在26,809名男性年龄在40至74岁的基线在1986年。研究参与者在基线时和此后每2年完成一次详细的问卷调查。听力损失的发病病例被定义为1986年以后专业诊断的病例。考克斯比例风险多变量回归用于调整潜在的混杂factors.Results：在386,081人年的后续行动，3447例听力损失事件的报告。总体而言，酒精摄入量与听力损失风险之间没有关联。与那些不饮酒的人相比，（95%置信区间）为1.00（0.89至1.12）为那些谁消耗5.0至9.9克/天，1.08（0.96至1.21）为10.0至14.9克/天，0.98（0.85至1.13）为30.0至49.9克/天。结果没有因年龄组或叶酸摄入量而异。然而，在维生素B12摄入量较低的人群中，饮酒量较高，特别是白酒，与听力损失风险增加有关。结论：我们的数据表明，低或中度饮酒不会影响老年男性听力损失的风险。维生素B12摄入量、饮酒量和听力损失之间的可能关系值得进一步研究。
Objective: Hearing loss is a common and disabling sensory disorder, yet prospective data on potentially modifiable risk factors are limited. Previous studies suggest that alcohol consumption may influence the development of hearing loss, yet results have been inconsistent. The purpose of this study was to prospectively examine the relation between alcohol use and hearing loss in men.Design: We examined prospectively the independent association between alcohol intake and self-reported professionally diagnosed hearing loss in 26,809 men aged 40 to 74 yrs at baseline in 1986. Study participants completed detailed questionnaires at baseline and every 2 yrs thereafter. Incident cases of hearing loss were defined as those professionally diagnosed after 1986. Cox proportional hazards multivariate regression was used to adjust for potential confounding factors.Results: During 386,081 person-years of follow-up, 3447 incident cases of hearing loss were reported. Overall, there was no association between level of alcohol intake and risk of hearing loss. Compared with those who did not consume alcohol, the multivariate-adjusted hazard ratios (95% confidence interval) were 1.00 (0.89 to 1.12) for those who consumed 5.0 to 9.9 g/day, 1.08 (0.96 to 1.21) for 10.0 to 14.9 g/day, and 0.98 (0.85 to 1.13) for 30.0 to 49.9 g/day. The results did not differ by age group or folate intake. Among those with lower intake of vitamin B12, however, higher consumption of alcohol, specifically liquor, was associated with an increased risk of hearing loss.Conclusions: Our data suggest that low or moderate alcohol consumption does not influence the risk of hearing loss in older men. A possible relation between vitamin B12 intake, alcohol consumption, and hearing loss merits further investigation.