A G protein-coupled receptor for UDP-glucose
A G protein-coupled receptor for UDP-glucose
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DOI：
10.1074/jbc.275.15.10767
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发表时间：
2000-04-14
影响因子：
4.8
通讯作者：
Livi, GP
中科院分区：
文献类型：
--
作者：
Chambers, JK;Macdonald, LE;Livi, GP
尿苷5‘-二磷酸葡萄糖(UDP-葡萄糖)在碳水化合物的酶促生物合成中作为糖基供体具有广泛的生物化学作用。目前尚不清楚UDP-葡萄糖可能具有药理活性，提示该分子可能存在一个受体，在这里，我们证明了UDP-葡萄糖和一些密切相关的分子，有效地激活了在酵母或哺乳动物细胞中异源表达的孤儿G蛋白偶联受体KIAA0001。已知的激活P2Y受体的核苷酸是无效的，这表明该受体具有独特的药理作用。该受体在多种人体组织中表达，包括大脑的许多区域。这些数据表明，一些糖核苷酸除了在中间代谢中扮演熟悉的角色外，还可能作为细胞外信号分子发挥重要的生理作用。
Uridine 5'-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is less well known that UDP-glucose may possess pharmacological activity, suggesting that a receptor for this molecule may exist, Here, we show that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells. Nucleotides known to activate P2Y receptors were inactive, indicating the distinctly novel pharmacology of this receptor. The receptor is expressed in a wide variety of human tissues, including many regions of the brain. These data suggest that some sugar-nucleotides may serve important physiological roles as extracellular signaling molecules in addition to their familiar role in intermediary metabolism.