Apolipoprotein H levels in diabetic subjects: correlation with cholesterol levels.
Apolipoprotein H levels in diabetic subjects: correlation with cholesterol levels.
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DOI：
10.1016/s0026-0495(97)90188-8
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发表时间：
1997-05
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影响因子：
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通讯作者：
M. Cassader;G. Ruiu;R. Gambino;F. Veglia;G. Pagano
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文献类型：
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作者：
M. Cassader;G. Ruiu;R. Gambino;F. Veglia;G. Pagano
为探讨糖尿病患者血浆载脂蛋白H（apo H）水平与血脂代谢的关系，我们对127例非胰岛素依赖型（NIDDM）和118例胰岛素依赖型（IDDM）糖尿病患者血浆apo H浓度与主要血脂水平进行了相关性研究。并与286例非糖尿病患者进行比较。我们的数据显示，与非糖尿病受试者相比，糖尿病受试者血浆apo H显著升高（NIDDM，29.9 ± 10.8 mg/dL; IDDM，31.3 ± 9.9;对照，22.5 ± 7.7; F = 53.3，P = 0.0001）。同时评价三组中血脂与载脂蛋白H之间的关系，模型中纳入糖尿病、性别、体重指数（BMI）和年龄作为协变量。该分析显示载脂蛋白H与总胆固醇之间存在强正相关性（P = 0.0009），与甘油三酯之间存在较弱的正相关性（[TG] P = 0.016）。糖尿病患者载脂蛋白H和血红蛋白A1 c（HbA 1c）水平之间的相关性（P = 0.03）突出了血糖控制对这种高度糖化的载脂蛋白血浆水平的重要性。虽然载脂蛋白H在脂质代谢中的作用仍不确定，但最近关于血浆载脂蛋白H水平与血脂升高和血栓形成风险之间可能关系的研究可以解释糖尿病患者动脉粥样硬化风险增加的原因。
To assess the relationship between apolipoprotein H (apo H) plasma levels and lipid metabolism in diabetes mellitus, we have examined the correlation between apo H plasma concentration and the main plasma lipid levels in 127 non—insulin-dependent (NIDDM) and 118 insulin-dependent (IDDM) diabetes mellitus patients. The data are compared with those in 286 nondiabetics. Our data show a significant increase in plasma apo H in diabetic as opposed to nondiabetic subjects (NIDDM, 29.9 ± 10.8 mg/dL; IDDM, 31.3 ± 9.9; controls, 22.5 ± 7.7; F = 53.3, P = .0001). The relation between plasma lipids and apo H was simultaneously evaluated in the three groups with inclusion of diabetes, sex, body mass index (BMI), and age as covariates in the model. This analysis showed a strong positive correlation (P = .0009) between apo H and total cholesterol, and a weaker positive correlation with triglycerides ([TGs] P = .016). The correlation between apo H and hemoglobin A1c(HbA1c) levels in diabetics (P = .03) highlights the importance of glycemic control for plasma levels of this apoprotein, which is highly glycated. Although the role of apo H in lipid metabolism is still uncertain, recent investigations on the possible relation between plasma apo H levels and increased plasma lipids and thrombotic risk could explain the increased atherosclerotic risk in diabetic patients.