Dynamical origin of independent spiking and bursting activity in neural microcircuits.
Dynamical origin of independent spiking and bursting activity in neural microcircuits.
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DOI：
10.1103/physrevlett.98.128106
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发表时间：
2007-03
影响因子：
8.6
通讯作者：
Thomas Nowotny;M. Rabinovich
中科院分区：
文献类型：
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作者：
Thomas Nowotny;M. Rabinovich
脉冲和爆发动力学之间的关系是神经科学中的一个关键问题，特别是在理解不同神经编码策略的起源以及运动指令产生和神经回路协调的机制方面。实验表明，脉冲动力学和爆发动力学是相互独立的。我们假设，不同的尖峰和短脉冲产生机制，尖峰的内在神经元动力学和短脉冲的调制网络不稳定性，是这种独立性的起源。我们在对三个相互连接的Hodgkin-Huxley神经元的最小抑制神经微电路(Motif)的详细动态分析中检验了这一假设。我们将这个高维动力学系统简化为一个速率模型，并证明了这两个系统从音调尖峰产生到爆发产生都有相同的分叉，因此，这与尖峰活动的细节无关。
The relationship between spiking and bursting dynamics is a key question in neuroscience, particularly in understanding the origins of different neural coding strategies and the mechanisms of motor command generation and neural circuit coordination. Experiments indicate that spiking and bursting dynamics can be independent. We hypothesize that different mechanisms for spike and burst generation, intrinsic neuron dynamics for spiking and a modulational network instability for bursting, are the origin of this independence. We tested the hypothesis in a detailed dynamical analysis of a minimal inhibitory neural microcircuit (motif) of three reciprocally connected Hodgkin-Huxley neurons. We reduced this high-dimensional dynamical system to a rate model and showed that both systems have identical bifurcations from tonic spiking to burst generation, which, therefore, does not depend on the details of spiking activity.