Effect of linoleic acid on proliferation and gene expression in the breast cancer cell line T47D.
Effect of linoleic acid on proliferation and gene expression in the breast cancer cell line T47D.
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DOI：
10.1016/j.canlet.2003.12.010
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发表时间：
2004-06
期刊：
影响因子：
9.7
通讯作者：
N. Reyes;Ismael Reyes;R. Tiwari;J. Geliebter
中科院分区：
文献类型：
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作者：
N. Reyes;Ismael Reyes;R. Tiwari;J. Geliebter
人类和动物研究已将 n-6 多不饱和脂肪酸与乳腺癌发生联系起来。我们研究了亚油酸对人乳腺癌细胞系 T47D 的细胞和分子影响。亚油酸对 T47D 细胞的生长有刺激作用，与细胞周期 S 期细胞比例的增加有关。微阵列、功能组和定量 PCR 分析表明，亚油酸可能通过调节雌激素受体 (ERα)、G13α G 蛋白和 p38 MAP 激酶基因表达以及参与 RNA 转录和细胞周期调节的基因来影响 T47D 细胞生长。
Human and animal studies have linked n-6 polyunsaturated fatty acids with mammary carcinogenesis. We investigated the cellular and molecular effects of linoleic acid on the human breast cancer cell line T47D. Linoleic acid had a stimulatory effect on the growth of T47D cells, associated with an increase in the proportion of cells in the S phase of the cell cycle. Microarray, functional group and quantitative PCR analyses indicate that linoleic acid may affect T47D cell growth by modulation of the estrogen receptor (ERα), the G13α G protein, and p38 MAP kinase gene expression as well genes involved in RNA transcription and cell cycle regulation.