Hemodynamic impact of proximal anterior cerebral artery aneurysm: Mind the posteriorly projecting ones!
Hemodynamic impact of proximal anterior cerebral artery aneurysm: Mind the posteriorly projecting ones!
复制标题
大脑前动脉近端动脉瘤对血流动力学的影响：注意向后突出的动脉瘤！
DOI：
10.1177/09544119221082420
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Xiaoyan Deng
中科院分区：
文献类型：
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作者：
Zhenmin Fan;Lijun Dong;Yingying Zhang;Xia Ye;Xiaoyan Deng
颅内动脉瘤向后突出与动脉瘤破裂的高风险相关。为了探讨不良事件的生物力学机制，根据临床数据构建了三维颅内动脉瘤，我们数值比较了动脉瘤的位置、位置、大小和形状对血流动力学条件（包括速度、压力和壁面切应力（WSS））的影响。数值结果表明，即使是小尺寸的动脉瘤，其向后突出也会导致异常的血流动力学环境，其特征是动脉瘤瘤颈附近的局部高压和应力集中。此外，位于A1段近端和椭圆形动脉瘤的一个会进一步恶化局部血流动力学环境，导致局部高应力。这些发现表明了向后突出的动脉瘤高破裂率的潜在机械机制，强调了早期准确诊断和及时治疗对改善临床结局的重要性，即使这些动脉瘤尺寸较小。
Intracranial aneurysm projected posteriorly is associated with high risk of aneurysm rupture. In order to investigate the biomechanical mechanisms for the adverse event, three-dimension intracranial cerebral aneurysms were constructed based on clinical data, and we numerically compared effect of location, position, size, and shape of aneurysm on hemodynamic conditions including velocity, pressure, and wall shear stress (WSS). The numerical results showed that the aneurysm projected posteriorly even at small sizes led to abnormal hemodynamic environment, which was featured by a local high pressure and stress concentration near aneurysm neck area. Moreover, the one located at the proximal A1 segment and ellipsoidal aneurysm would further worse local hemodynamic environment, causing high local stresses. These findings indicated the potential mechanical mechanism for high rupture rate of the aneurysms projected posteriorly, underscoring importance of early and accurate diagnosis and promptly treatment for improved the clinical outcome, even if these aneurysms are of small sizes.