Role of endothelin in the increased vascular tone of patients with essential hypertension
Role of endothelin in the increased vascular tone of patients with essential hypertension
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DOI：
10.1161/01.hyp.33.2.753
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发表时间：
1999-02-01
期刊：
影响因子：
8.3
通讯作者：
Panza, JA
中科院分区：
文献类型：
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作者：
Cardillo, C;Kilcoyne, CM;Panza, JA
我们使用内皮素受体拮抗剂研究了内皮素在高血压患者血管收缩张力增加中的可能作用。在高血压患者和血压正常的对照组中，测量了前臂血流（FBF）对动脉内输注内皮素-A（ETA）（BQ-123）和内皮素-B（ETB）（BQ-788）受体阻断剂的反应（应变计体积描记法）。在健康受试者中，单独使用BQ-123或与BQ-788联合使用不会显著改变FBF（分别为P=0.78和P=0.63）。相反，在高血压患者中，BQ-123使FBF增加33+/-7%（P
We investigated the possible role of endothelin in the increased vasoconstrictor tone of hypertensive patients using antagonists of endothelin receptors. Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intraarterial infusion of blockers of endothelin-A (ETA) (BQ-123) and endothelin-B (ETB) (BQ-788) receptors, separately and in combination, were measured in hypertensive patients and normotensive control subjects. In healthy subjects, BQ-123 alone or in combination with BQ-788 did not significantly modify FBF (P=0.78 and P=0.63, respectively). In hypertensive patients, in contrast, BQ-123 increased FBF by 33+/-7% (P