Biochemical evidence of decreased muscarinic cholinergic neuronal communication following amygdala-kindled seizures.
Biochemical evidence of decreased muscarinic cholinergic neuronal communication following amygdala-kindled seizures.
复制标题
杏仁核引发的癫痫发作后毒蕈碱胆碱能神经元通讯减少的生化证据。
DOI：
10.1016/0006-8993(81)90123-2
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
McNamara,JO
中科院分区：
文献类型：
--
作者：
Dasheiff,RM;Byrne,MC;Patrone,V;McNamara,JO
用雄性SD大鼠建立癫痫点燃模型，对M胆碱能神经元通讯的多种生化成分进行了系统的分析。整个边缘系统都可以检测到M受体的减少，其中齿状回的减少最为明显。受体的下降最初是在点燃发展的后期发现的，在点燃完成后1天最大，并在1周后恢复正常。(参考文献16)
Presents a systematic analysis of multiple biochemical components of muscarinic cholinergic neuronal communication in the kindling model of epilepsy, using male Sprague-Dawley rats. Reductions of muscarinic receptors were detected throughout the limbic system, being greatest in the dentate gyri. The receptor declines were initially found late during the development of kindling, were maximal 1 day following completion of kindling, and returned to normal 1 wk later.(16 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)