MOTOR UNIT FUNCTION IN SKELETAL-MUSCLE AUTOGRAFTS OF RATS
MOTOR UNIT FUNCTION IN SKELETAL-MUSCLE AUTOGRAFTS OF RATS
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DOI：
10.1016/0014-4886(84)90226-7
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发表时间：
1984-01-01
影响因子：
5.3
通讯作者：
FAULKNER, JA
中科院分区：
文献类型：
--
作者：
COTE, C;FAULKNER, JA
标准和神经完整的大鼠指长伸肌（EDL）移植物不能完全恢复最大强直张力（Po）的控制值。对大鼠标准EDL和完整EDL神经移植后运动单元的生理特性进行了比较。标准移植物被完全移除，并在其原始位置替换。对于神经完整的移植物，除神经外，所有物理连接都被切断。手术后75天和50天，分别测量标准和神经完整移植物的全肌肉和单个运动单元的等长收缩特性。两种移植物的运动单元显示出峰值抽动张力（TPT）的平均值和分布与对照运动单元没有区别。神经完整移植物的绝对Po值较标准移植物恢复较大，但仍显著低于对照组。神经完整移植物的运动单位Po平均下降16%，与总EDL移植物的Po下降没有什么不同，这表明神经完整移植物没有运动单位的损失。在标准移植物中，整个肌肉的Po减少了57%，这是由于每个运动单元的平均张力发展减少了20%，运动单元的数量减少了45%。这些差异表明神经完整的移植物比标准移植物的神经再生更完整。
Standard and nerve-intact grafts of the extensor digitorum longus (EDL) muscles of rats do not fully recover control values for maximum tetanic tension (Po). The physiologic properties of motor units from standard and nerve-intact EDL grafts of rats were compared with those of control EDL muscles. Standard grafts were completely removed and replaced in their original site. For nerve-intact grafts all physical connections were severed except for the nerve. Isometric contractile properties of whole muscles and single motor units were measured in situ 75 and 50 days after surgery for standard and nerve-intact grafts, respectively. Motor units from both types of grafts showed a mean and distribution for time-to-peak twitch tension (TPT) not different from control motor units. The absolute Po of nerve-intact grafts showed a greater recovery than the standard grafts, but was still significantly lower than the control value. The average decrease in the Po of motor units from nerve-intact grafts of 16% was not different from the decrease in the Po of the total EDL graft which suggests no loss of motor units in nerve-intact grafts. In standard grafts, the 57% decrease in Po for the whole muscle was attributable to a 20% decrease in the average tension development per motor unit and a 45% decrease in the number of motor units. These differences suggest a more complete reinnervation of the nerve-intact grafts than standard grafts.