NEUTROPHIL INFLUX INTO AN INFLAMMATORY SITE INHIBITED BY A SOLUBLE HOMING RECEPTOR-IGG CHIMERA
NEUTROPHIL INFLUX INTO AN INFLAMMATORY SITE INHIBITED BY A SOLUBLE HOMING RECEPTOR-IGG CHIMERA
复制标题
DOI：
10.1038/349164a0
复制
发表时间：
1991-01-10
期刊：
影响因子：
64.8
通讯作者：
LASKY, LA
中科院分区：
文献类型：
--
作者：
WATSON, SR;FENNIE, C;LASKY, LA
中性粒细胞介导的炎症参与了许多人类临床表现，包括成人呼吸窘迫综合征、多器官衰竭和再灌注损伤1。 抑制这种类型的炎症反应的一种方法是竞争性地阻断嗜中性粒细胞和邻近发炎区域2的内皮之间的粘附相互作用。 含凝集素的3，4鼠粘附分子gp90MET，归巢受体，发现在所有白细胞细胞，包括中性粒细胞。5 MEL 14，一种针对这种粘附分子的单克隆抗体，阻断淋巴细胞向淋巴结的运输6和嗜中性粒细胞从血液向炎症部位的外渗7。 在这里，我们表明，给小鼠施用含有鼠归巢受体胞外结构域的可溶性免疫球蛋白嵌合体显著减少了响应于炎性刺激物巯基乙酸盐而迁移到腹膜的中性粒细胞的数量。 这些结果表明，可溶形式的单一类型的粘附分子，归巢受体，可能是临床有效的化合物，用于抑制嗜中性粒细胞介导的炎症。
Neutrophil-mediated inflammation is involved in a number of human clinical manifestations, including the adult respiratory distress syndrome, multi-organ failure and reperfusion injury 1. One way of inhibiting this type of inflammatory response would be to block competitively the adhesive interactions between neutrophils and the endothelium adjacent to the inflamed region 2. The lectin-containing 3,4 murine adhesion molecule gp90MET, the homing receptor, is found on all leukocytic cells, including neutrophils. 5 MEL 14, a monoclonal antibody directed against this adhesion molecule, blocks lymphocyte traffic to lymph nodes 6 and extravasation of neutrophils from blood to inflammatory sites 7. Here we show that administration to mice of a soluble immunoglobulin chimaera containing the murine homing receptor extracellular domain significantly decreases the number of neutrophils that migrate to the peritoneum in response to the inflammatory irritant thioglycollate. These results indicate that soluble forms of a single type of adhesion molecule, the homing receptor, could be clinically effective compounds for the inhibition of neutrophil-mediated inflammation.