Influence of eye colors of Caucasians and Asians on suppression of melatonin secretion by light
Influence of eye colors of Caucasians and Asians on suppression of melatonin secretion by light
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DOI：
10.1152/ajpregu.00355.2006
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发表时间：
2007-06-01
影响因子：
2.8
通讯作者：
Maeda, Takafumi
中科院分区：
文献类型：
--
作者：
Higuchi, Shigekazu;Motohashi, Yutaka;Maeda, Takafumi
本实验测试了人眼色素沉着对光线抑制夜间褪黑激素分泌的影响。10名拥有蓝色、绿色或浅棕色虹膜的健康高加索男性（浅色眼睛的高加索人）和11名拥有深棕色虹膜的亚洲男性（深色眼睛的亚洲人）自愿参加了这项研究。浅色眼睛白种人和深色眼睛亚洲人的平均年龄分别为26.4 +/- 3.2岁和25.3 +/- 5.7岁。受试者在夜间暴露于光照（1000勒克斯）下2小时。暴露开始时间设定为每位受试者唾液褪黑素浓度峰值时间前2小时，该时间在初步实验中确定。在光照前和光照中测量唾液褪黑素浓度和瞳孔大小。计算光对褪黑激素分泌抑制的百分比。光照开始2 h后，浅色眼白种人的褪黑激素分泌抑制率（88.9 +/- 4.2%）显著高于深色眼白种人（73.4 +/- 20.0%）（P < 0.01）。浅色眼睛的白种人和深色眼睛的亚洲人的瞳孔大小没有显著差异。这些结果表明，褪黑激素对光抑制的敏感性受到眼睛色素沉着和/或种族的影响。
This experiment tested effects of human eye pigmentation depending on the ethnicity on suppression of nocturnal melatonin secretion by light. Ten healthy Caucasian males with blue, green, or light brown irises (light-eyed Caucasians) and 11 Asian males with dark brown irises (dark-eyed Asians) volunteered to participate in the study. The mean ages of the light-eyed Caucasians and dark-eyed Asians were 26.4 +/- 3.2 and 25.3 +/- 5.7 years, respectively. The subjects were exposed to light (1,000 lux) for 2 h at night. The starting time of exposure was set to 2 h before the time of peak salivary melatonin concentration of each subject, which was determined in a preliminary experiment. Salivary melatonin concentration and pupil size were measured before exposure to light and during exposure to light. The percentage of suppression of melatonin secretion by light was calculated. The percentage of suppression of melatonin secretion 2 h after the start of light exposure was significantly larger in light-eyed Caucasians (88.9 +/- 4.2%) than in dark-eyed Asians (73.4 +/- 20.0%) (P < 0.01). No significant difference was found between pupil sizes in light-eyed Caucasians and dark-eyed Asians. These results suggest that sensitivity of melatonin to light suppression is influenced by eye pigmentation and/or ethnicity.