A Differential Electrochemical Readout ASIC With Heterogeneous Integration of Bio-Nano Sensors for Amperometric Sensing
A Differential Electrochemical Readout ASIC With Heterogeneous Integration of Bio-Nano Sensors for Amperometric Sensing
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DOI：
10.1109/tbcas.2017.2733624
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发表时间：
2017-10-01
影响因子：
5.1
通讯作者：
Georgiou, Pantelis
中科院分区：
文献类型：
--
作者：
Ghoreishizadeh, Sara S.;Taurino, Irene;Georgiou, Pantelis
提出了一种基于CMOS的小型化电流型电化学生物传感平台。该系统包括一个用于差分电流测量的完全集成的电流读出电路，以及通过在顶部金属层实现的电极顶部生长铂纳米结构（Pt-nanoS）开发的芯片上传感器。该电路是基于开关电容技术，并包括伪差分积分器的差分传感器电流的并发采样。该电路还包括在ADC之前的差分至单路转换器和可编程增益放大器。该系统采用0.35 μ m工艺制造，测量电流在+/- 20 μ A范围内，最小输入参考噪声为0.47 pA，3.3 V电源供电时功耗为9.3 mW。提出了用于纳米结构传感器的差分传感，以构建用于代谢物检测的高灵敏度和无偏移传感器。这是成功地测试了生物纳米传感器的测量葡萄糖在亚毫摩尔浓度与建议的读出IC。芯片上的电极是纳米结构的，循环伏安法通过读出IC成功运行，以证明H2 O2的检测。
A monolithic biosensing platform is presented for miniaturized amperometric electrochemical sensing inCMOS. The system consists of a fully integrated current readout circuit for differential current measurement as well as on-die sensors developed by growing platinum nanostructures (Pt-nanoS) on top of electrodes implemented with the top metal layer. The circuit is based on the switch-capacitor technique and includes pseudodifferential integrators for concurrent sampling of the differential sensor currents. The circuit further includes a differential to single converter and a programmable gain amplifier prior to an ADC. The system is fabricated in 0.35 mu m technology and measures current within +/- 20 mu A with minimum input-referred noise of 0.47 pA and consumes 9.3 mW from a 3.3 V supply. Differential sensing for nanostructured sensors is proposed to build highly sensitive and offsetfree sensors for metabolite detection. This is successfully tested for bio-nano-sensors for the measurement of glucose in submilli molar concentrations with the proposed readout IC. The on-die electrodes are nanostructured and cyclic voltammetry run successfully through the readout IC to demonstrate detection of H2O2.