The complete genome sequence of the gastric pathogen Helicobacter pylori
The complete genome sequence of the gastric pathogen Helicobacter pylori
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DOI：
10.1038/41483
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发表时间：
1997-08-07
期刊：
影响因子：
64.8
通讯作者：
Venter, JC
中科院分区：
文献类型：
--
作者：
Tomb, JF;White, O;Venter, JC
幽门螺杆菌，菌株 26695，具有 1,667,867 个碱基对和 1,590 个预测编码序列的环状基因组。序列分析表明，幽门螺杆菌具有发达的运动系统、铁清除系统以及 DNA 限制和修饰系统。鉴定出许多假定的粘附素、脂蛋白和其他外膜蛋白，强调了 宿主-病原体相互作用的潜在复杂性，基于编码外膜蛋白的大量序列相关基因以及编码序列中同聚束和二核苷酸重复的存在，幽门螺杆菌与其他几种粘膜病原体一样，可能使用重复内的重组和滑链错配作为抗原变异和适应性进化的机制，与其限制一致 在生态位中，幽门螺杆菌具有一些调节网络，以及有限的代谢库和生物合成能力，其在酸性条件下的生存部分取决于其在低pH值下建立正内膜电位的能力。
Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences, Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification, Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction, Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution, Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity, Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.