Shock-induced hyperalgesia: II. Role of the dorsolateral periaqueductal gray.
Shock-induced hyperalgesia: II. Role of the dorsolateral periaqueductal gray.
复制标题
电击引起的痛觉过敏：II。
DOI：
10.1037//0735-7044.113.3.539
复制
发表时间：
1999
影响因子：
1.9
通讯作者：
Grau,JW
中科院分区：
文献类型：
--
作者：
McLemore,S;Crown,ED;Meagher,MW;Grau,JW
Exposure to 3 moderately intense (1-mA) tailshocks has been shown to lower vocalization thresholds to both heat and shock. Previous shock exposure also facilitates the acquisition of conditioned fear as measured by freezing. These observations suggest that shock induces hyperalgesia (enhanced pain). This study explored whether shock-induced hyperalgesia depends on neurons within rostral or caudal portions of the dorsolateral periaqueductal gray (dlPAG). Experiment 1 examined the impact of dlPAG lesions on the acquisition of conditioned fear. Sham-operated rats demonstrated enhanced acquisition after shock exposure; both rostral and caudal lesions eliminated this effect. Experiment 2 showed that tailshock lowered vocalization thresholds to heat in sham-operated but not lesioned subjects. These results suggest that the dlPAG plays a critical role in the production of shock-induced hyperalgesia.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
