Serum irisin levels as a potential marker for diagnosis of gestational diabetes mellitus.
Serum irisin levels as a potential marker for diagnosis of gestational diabetes mellitus.
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DOI：
10.23750/abm.v91i1.7675
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发表时间：
2020-03-19
期刊：
影响因子：
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通讯作者：
Al-Rufaie MM
中科院分区：
文献类型：
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作者：
Al-Ghazali MJ;Ali HA;Al-Rufaie MM
本研究旨在比较妊娠期糖尿病（GDM）孕妇与正常孕妇血清中鸢尾素及微量元素（Zn、Cu、Mg）的水平。60例GDM孕妇和30例健康孕妇。两组产妇年龄、孕周相匹配。采用酶联免疫吸附法测定孕24-28周孕妇血清中鸢尾素水平。母体血清鸢尾素水平和临床和生化参数之间的关联进行了评估。对研究组和对照组的体重指数、血糖、OGTT、胰岛素、HbA 1C、HOMA IR、HOMAβ、Hb%、鸢尾素等指标进行分析。妊娠期糖尿病孕妇空腹血糖明显高于对照组（p = 0.004），第1小时OGTT葡萄糖（p = 0.001），第二小时OGTT葡萄糖（p = 0.001）、空腹胰岛素FI（p = 0.001）水平、HOMA IR（p = 0.001）、HOMAβ（p = 0.001）、HbA 1C（p = 0.001）、Hb%（p = 0.017）。随后发生GDM的妇女（平均值± SD =71.65±8.03）的血清鸢尾素水平显著低于健康妊娠对照（平均值± SD 136.54±22.56）（p =0.001）。妊娠期糖尿病患者血清中鸢尾素水平与人体测量学和生化指标的相关性分析显示，所调查的参数与血清中鸢尾素水平无关。本研究结果表明，血清中鸢尾素水平可能作为一种新的标志物GDM，降低水平的鸢尾素是GDM的症状。()
The aim of this study was to compare serum irisin, trace elements (Zn, Cu, Mg) levels between the group of pregnant women with gestational diabetes mellitus (GDM) and healthy pregnant group. Sixty pregnant women with GDM and 30 healthy pregnant women. The two groups were matched for maternal age, gestational age. Maternal serum irisin levels were measured by enzyme-linked immunosorbent assay kit at 24-28 weeks of gestation. An association between maternal serum irisin levels and clinical and biochemical parameters was evaluated. Body mass index, serum levels of glucose, OGTT, insulin, HbA1C, HOMA IR, HOMAβ, Hb%, and irisin were investigated and analyzed in the study group and controls. Pregnant women with GDM had significantly higher fasting blood glucose FBG (p = 0.004), first-houEr OGTT glucose (p = 0.001), second-hour OGTT glucose (p = 0.001), fasting insulin FI (p = 0.001) levels, HOMA IR (p = 0.001), HOMAβ (p = 0.001), HbA1C(p = 0.001), Hb% (p = 0.017), as compared to controls. serum irisin levels were significantly lower (p =0.001) in women subsequently developed GDM (mean ± SD =71.65±8.03) than healthy pregnant controls (mean ± SD 136.54±22.56). Correlation analysis between irisin levels and anthropometric and biochemical parameters in patients with gestational diabetes revealed that none of the investigated parameters correlated with serum irisin level. The present results suggest that serum irisin levels might presented as a novel marker for GDM, with decreased levels of irisin being symptomatic of GDM. ()