CHANGES IN ELECTRICAL-ACTIVITY OF MYOMETRIUM DURING INTRAUTERINE DISTRIBUTION OF RAT BLASTOCYSTS AND AFTER PRAZOSIN ADMINISTRATION
CHANGES IN ELECTRICAL-ACTIVITY OF MYOMETRIUM DURING INTRAUTERINE DISTRIBUTION OF RAT BLASTOCYSTS AND AFTER PRAZOSIN ADMINISTRATION
复制标题
DOI：
10.1530/jrf.0.0860039
复制
发表时间：
1989-05-01
期刊：
影响因子：
--
通讯作者：
MALTIER, JP
中科院分区：
文献类型：
--
作者：
LEGRAND, C;BANUELOSNEVAREZ, A;MALTIER, JP
在妊娠早期大鼠中，子宫肌层的电活动包括有规律的峰电位爆发，其在妊娠第2天传播良好。在第3天，有一个逐渐消失的传播活动。同时，子宫孕酮浓度增加了7倍（P < 0.001）。在这个阶段，爆发的平均持续时间为15.2 ±。0.9爆发之间完全静止的时间间隔为84.2 ± 1.5秒。7.0秒第4天10：00时，雌二醇和孕酮的子宫浓度出现峰值，分别为第2天值的+36%和+654%（P < 0.05）。第4天10：00 ~ 20：00，肌电活动出现短暂的快速上升，子宫角输卵管端的爆发持续时间较长（+60%，P < 0.05），棘波振幅增加（输卵管端和宫颈端分别为+67%，P < 0.05）。哌唑嗪剂量依赖性地可逆性抑制肌电活动，2-3 h后达到最大抑制。可以得出结论，在EMG记录期间观察到的变化与胚泡的子宫内分布有关，并且与类固醇环境的变化和/或通过α 1-肾上腺素受体的儿茶酚胺作用有关。
In the early pregnant rat, electrical activity of the myometrium consisted of regular bursts of spike potential, which appeared well propagated on Day 2 of pregnancy. During Day 3, there was a gradual disappearance of propagated activity. Concomitantly, there was a 7-fold increase (P < 0.001) of uterine progesterone concentrations. At this stage, mean duration of bursts was 15.2 .+-. 0.9 sec and intervals of complete quiescence between bursts were 84.2 .+-. 7.0 sec. At 10:00 h on Day 4, there were peaks in the uterine concentrations of estradiol and progesterone, +36% and +654%, respectively, compared with values on Day 2 (P < 0.05). Between 10:00 and 20:00 h on Day 4, EMG activity exhibited a rapid and transient rise: bursts were of longer duration at the utero-tubal end of the horn (+60%, P < 0.05) with an increased amplitude of spike potentials (+67% and +90% respectively at the tubal and cervical ends of the uterus, P < 0.05). The administration of prazosin depressed EMG activity reversibly in a dose-dependent manner with maximal inhibition at about 2-3 h later. It is concluded that the changes observed during EMG recordings are relevant to the intrauterine distribution of blastocysts and related to changes in the steroidal environment and/or to catecholamine effects via .alpha.1-adrenoceptors.