The metabolic syndrome in pregnancy and its association with child telomere length
The metabolic syndrome in pregnancy and its association with child telomere length
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DOI：
10.1007/s00125-020-05242-0
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发表时间：
2020-07-29
期刊：
影响因子：
8.2
通讯作者：
Grieger, Jessica A.
中科院分区：
文献类型：
--
作者：
McAninch, Dale;Bianco-Miotto, Tina;Grieger, Jessica A.
目的/假设本研究的目的是确定是否存在代谢综合征在怀孕与儿童端粒长度或儿童人体测量方法妊娠终点筛查研究（SCOPE）是一项多中心、国际前瞻性队列研究，从澳大利亚、新西兰、爱尔兰和英国（N = 5628）。目前的分析是对来自澳大利亚队列的SCOPE孕妇及其子女进行的10年随访。在SCOPE研究期间收集的妊娠14-16周的临床数据用于使用IDF标准诊断代谢综合征。端粒长度，老化的生物标志物，从儿童的唾液收集在10岁的age.Results定量PCR进行评估，在妇女完成随访（n = 255），20%的代谢综合征在怀孕期间。在调整了一系列混杂因素后，妊娠期患有代谢综合征的母亲的子女比妊娠期没有代谢综合征的母亲的子女的端粒短14%（平均差异-0.36 [95%CI-0.74，0.01]）。身高和体重的年龄，和BMI分数是相似的母亲谁没有和没有代谢综合征在怀孕期间。结论/解释儿童的母亲谁有代谢综合征在怀孕期间有较短的端粒，加速老化的生物标志物。这些发现需要在更大的儿童队列中进行进一步的研究，以及调查脐带血中测量的端粒长度是否与儿童时期的端粒长度相关。
Aims/hypothesis The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age.Methods The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international prospective cohort of nulliparous pregnant women recruited from Australia, New Zealand, Ireland and the UK (N = 5628). The current analysis is a 10 year follow-up of SCOPE pregnant women and their children, from the Australian cohort. Clinical data collected at 14-16 weeks' gestation during the SCOPE study were used to diagnose the metabolic syndrome using IDF criteria. Telomere length, a biomarker of ageing, was assessed by quantitative PCR from children's saliva collected at 10 years of age.Results In women who completed follow-up (n = 255), 20% had the metabolic syndrome in pregnancy. After adjusting for a range of confounders, children of mothers who had the metabolic syndrome in pregnancy had 14% shorter telomeres than children of mothers without the metabolic syndrome in pregnancy (mean difference -0.36 [95% CI -0.74, 0.01]). Height- and weight-for-age, and BMIzscores were similar in children of mothers who did and did not have the metabolic syndrome during pregnancy.Conclusions/interpretation Children of mothers who had the metabolic syndrome in pregnancy have shorter telomeres, a biomarker of accelerated ageing. These findings warrant further studies in larger cohorts of children, as well as investigations into whether telomere length measured in cord blood associates with telomere length in childhood.