Biodegradable polymers exhibiting temperature-responsive sol-gel transition as injectable biomedical materials
Biodegradable polymers exhibiting temperature-responsive sol-gel transition as injectable biomedical materials
复制标题
DOI：
10.1016/j.reactfunctpolym.2012.11.003
复制
发表时间：
2013-07-01
影响因子：
5.1
通讯作者：
Ohya, Yuichi
中科院分区：
文献类型：
--
作者：
Nagahama, Koji;Takahashi, Akihiro;Ohya, Yuichi
可注射生物可降解共聚物水凝胶具有温度响应性的溶胶-凝胶转变特性，近年来在药物输送、细胞植入、组织工程等生物医学领域受到广泛关注。这些可注射水凝胶可以在手术创伤最小的情况下植入人体。温度响应性凝胶共聚物通常具有嵌段和/或支化结构和两亲性，具有微妙的疏水/亲水平衡。聚乙二醇(PEG)由于其生物相容性和温度依赖性脱水性质，通常被用作亲水性链段。聚乳酸、聚(丙交酯-乙交酯)、聚(己内酯)等脂肪族聚酯及其改性共聚物因其生物降解性和生物相容性而被用作疏水链段。聚乙二醇与其他疏水聚合物如多肽、多肽的共聚物最近也被报道为可注射水凝胶。本文综述了可注射生物降解聚合物水凝胶的发展简史和最新进展，重点介绍了聚合物结构与凝胶性能之间的关系。此外，还介绍了这些可注射聚合物凝胶在药物输送和组织工程等生物医学领域的应用。(C)2012爱思唯尔有限公司。保留所有权利。
Injectable biodegradable copolymer hydrogels, which exhibit temperature-responsive sol-to-gel transition, have recently drawn much attention as promising biomedical materials such as drug delivery, cell implantation, and tissue engineering. These injectable hydrogels can be implanted in the human body with minimal surgical invasion. Temperature-responsive gelling copolymers usually possess block- and/or branched architectures and amphiphilicity with a delicate hydrophobic/hydrophilic balance. Poly(ethylene glycol) (PEG) has typically been used as hydrophilic segments due to its biocompatibility and temperature-dependent dehydration nature. Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide), poly(epsilon-caprolactone), and their modified copolymers have been used as hydrophobic segments based on their biodegradability and biocompatibility. Copolymers of PEG with other hydrophobic polymers such as polypeptides, polydepsipeptides have also been recently reported as injectable hydrogels. In this review, brief history and recent advances in injectable biodegradable polymer hydrogels are summarized especially focusing on the relationship between polymer architecture and their gelation properties. Moreover, the applications of these injectable polymer gels for biomedical use such as drug delivery and tissue engineering are also described. (C) 2012 Elsevier Ltd. All rights reserved.