A cost-benefit analysis of the physical mechanisms of membrane curvature.
A cost-benefit analysis of the physical mechanisms of membrane curvature.
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DOI：
10.1038/ncb2832
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发表时间：
2013-09
影响因子：
21.3
通讯作者：
中科院分区：
文献类型：
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许多细胞膜结合结构表现出明显的曲率，这是由它们的脂质和蛋白质成分的物理性质驱动的。在这里，我们回顾了细胞如何操纵和控制这种曲率的背景下，如囊泡介导的膜交通的动态事件。脂质和货物蛋白各自贡献囊泡形成期间必须克服的能量屏障。相反，蛋白质外壳和它们相关的辅助蛋白使用各种相互依赖的物理机制驱动膜弯曲。我们调查的精力充沛的成本和驱动程序参与膜曲率，绘制分子拥挤的随机贡献和确定性组装的蛋白质外套之间的对比。这些基本原理也适用于其他细胞膜弯曲事件的例子，包括重要的疾病相关问题，如病毒外流。
Many cellular membrane-bound structures exhibit distinct curvature that is driven by the physical properties of their lipid and protein constituents. Here we review how cells manipulate and control this curvature in the context of dynamic events such as vesicle-mediated membrane traffic. Lipids and cargo proteins each contribute energetic barriers that must be overcome during vesicle formation. In contrast, protein coats and their associated accessory proteins drive membrane bending using a variety of interdependent physical mechanisms. We survey the energetic costs and drivers involved in membrane curvature, drawing a contrast between the stochastic contributions of molecular crowding and the deterministic assembly of protein coats. These basic principles also apply to other cellular examples of membrane bending events, including important disease-related problems like viral egress.