Alzheimer disease and Down syndrome: factors in pathogenesis
Alzheimer disease and Down syndrome: factors in pathogenesis
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DOI：
10.1016/j.neurobiolaging.2004.08.005
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发表时间：
2005-03-01
影响因子：
4.2
通讯作者：
Head, E
中科院分区：
文献类型：
--
作者：
Lott, IT;Head, E
有证据表明，在一般人群中，血管疾病和阿尔茨海默病（AD）的发病机制存在某些共同特征。在唐氏综合征（DS）中，所有40岁以上的成年人都发生了足以诊断AD的神经病理学。然而，血管疾病在DS中并不像在普通人群中那样常见，特别是在动脉粥样硬化的发展方面。我们讨论的生物学机制和危险因素，可能是共同的两种疾病，包括胆固醇代谢，炎症，纤溶酶原激活物抑制剂和载脂蛋白E（Apo E）。对DS患者的研究可能有助于确定常见的致病联系以及血管疾病和AD之间的分离。(C)2004爱思唯尔公司All rights reserved.
There is evidence to suggest that certain shared features exist in the pathogenesis of vascular disease and Alzheimer disease (AD) in the general population. In Down syndrome (DS) all adults over the age of 40 years develop sufficient neuropathology for a diagnosis of AD. However, vascular disease is not as common in DS as it is in the general population, particularly with respect to the development of atheromas. We discuss biological mechanisms and risk factors that may be common to both diseases including cholesterol metabolism, inflammation, plasminogen activator inhibitor and apolipoprotein E (Apo E). The study of individuals with DS may help to identify common pathogenic links as well as a disassociation between vascular disease and AD. (C) 2004 Elsevier Inc. All rights reserved.