Prevention of Peritendinous Adhesions with Electrospun Ibuprofen-Loaded Poly(L-Lactic Acid)-Polyethylene Glycol Fibrous Membranes
Prevention of Peritendinous Adhesions with Electrospun Ibuprofen-Loaded Poly(L-Lactic Acid)-Polyethylene Glycol Fibrous Membranes
复制标题
用静电纺丝负载布洛芬的聚（L-乳酸）-聚乙二醇纤维膜预防腱周粘连
DOI：
10.1089/ten.tea.2012.0208
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发表时间：
2013-02-01
影响因子：
4.1
通讯作者：
Fan, Cunyi
中科院分区：
文献类型：
--
作者：
Liu, Shen;Hu, Changmin;Fan, Cunyi
物理屏障通常用于减少损伤后腱周粘连。然而，对手术的炎症反应是无法预防的。本研究旨在评价负载布洛芬的聚（L-乳酸）-聚乙二醇（PELA）二嵌段共聚物纤维膜在预防粘连形成和减轻炎症方面的能力。电纺PELA纤维膜进行了机械测试，其特征在于形态，表面润湿性，药物释放，和降解。体外释药研究结果表明，布洛芬初始含量高时，纤维膜呈突释，随后为缓释。与组织培养板或不含布洛芬的PELA纤维膜相比，在负载布洛芬的PELA纤维膜上粘附和增殖的L929小鼠成纤维细胞较少。在鸡趾深屈肌腱手术模型中，负载布洛芬的PELA纤维膜防止组织粘连并显著减少炎症。综上所述，这些结果表明负载布洛芬的PELA纤维膜通过抗粘连和抗炎作用比不含布洛芬的膜更好地防止腱周粘连形成。
Physical barriers are commonly used to reduce peritendinous adhesion after injury. However, the inflammatory response to surgery cannot be prevented. This study was designed to evaluate the ability of ibuprofen-loaded poly(l-lactic acid)-polyethylene glycol (PELA) diblock copolymer fibrous membranes in preventing adhesion formation and reduce inflammation. Electrospun PELA fibrous membranes underwent mechanical testing and were characterized by morphology, surface wettability, drug release, and degradation. Results of an in vitro drug release study showed that a burst release was followed by sustained release from fibrous membranes with high initial ibuprofen content. Fewer L929 mouse fibroblasts adhered to and proliferated on the ibuprofen-loaded PELA fibrous membrane compared with tissue culture plates or PELA fibrous membrane without ibuprofen. In a chicken model of flexor digitorum profundus tendon surgery, the ibuprofen-loaded PELA fibrous membranes prevented tissue adhesion and significantly reduced inflammation. Taken together, these results demonstrate that ibuprofen-loaded PELA fibrous membranes prevent peritendinous adhesion formation better than membranes that do not contain ibuprofen, through anti-adhesion and anti-inflammatory actions.