Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study
Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study
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DOI：
10.1182/blood-2011-04-349688
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发表时间：
2012-03-22
期刊：
影响因子：
20.3
通讯作者：
Peters, Christina
中科院分区：
文献类型：
--
作者：
Styczynski, Jan;Balduzzi, Adriana;Peters, Christina
我们前瞻性地调查了453例儿童供者造血干细胞（HSC）采集安全性的影响因素。根据中心政策，研究中的儿童捐献了BM或外周血干细胞（PBSC）。在参与研究的中心之间观察到供体问题的方法存在很大差异。在疼痛、同种异体输血、住院时间和补铁方面，观察到BM和PBSC供体之间存在显著差异;然而，接受BM与PBSC供体的组之间的差异排除了2种程序之间的直接风险比较。最常见的不良事件是疼痛，主要由年龄较大的儿童在BM采集后报告，但也在放置中心静脉导管（CVC）采集PBSC后观察到。关于严重不良事件，1例患者（0.7%）在放置CVC采集PBSC后发生气胸伴胸腔积液。骨髓收获后同种异体输血的风险与供体年龄< 4 years and a BM harvest volume of >20 mL/kg相关。< 4岁的儿童在BM收获后异体输血的风险高于年龄较大的儿童，并且在单采前CVC放置的并发症风险较高。我们得出结论，PBSC和BM收集是安全的程序在儿童。（血。2012;119（12）：2935-2942）
We investigated prospectively factors influencing the safety of hematopoietic stem cell (HSC) collection in 453 pediatric donors. The children in the study donated either BM or peripheral blood stem cells (PBSCs) according to center policy. A large variability in approach to donor issues was observed between the participating centers. Significant differences were observed between BM and PBSC donors regarding pain, blood allotransfusion, duration of hospital stay, and iron supplementation; however, differences between the groups undergoing BM vs PBSC donation preclude direct risk comparisons between the 2 procedures. The most common adverse event was pain, reported mainly by older children after BM harvest, but also observed after central venous catheter (CVC) placement for PBSC collection. With regard to severe adverse events, one patient (0.7%) developed a pneumothorax with hydrothorax after CVC placement for PBSC collection. The risk of allotransfusion after BM harvest was associated with a donor age of < 4 years and a BM harvest volume of > 20 mL/kg. Children < 4 years were at higher risk than older children for allotransfusion after BM harvest and there was a higher risk of complications from CVC placement before apheresis. We conclude that PBSC and BM collection are safe procedures in children. (Blood. 2012;119(12):2935-2942)