Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration
Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration
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DOI：
10.1210/jc.2002-020953
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发表时间：
2003-03-01
影响因子：
5.8
通讯作者：
Lupoli, G
中科院分区：
文献类型：
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作者：
Vitale, G;Lupoli, GA;Lupoli, G
重组人促甲状腺激素（rhTSH）已被提出作为一种替代方法，以消除甲状腺激素在后续的分化型甲状腺癌。本研究的目的是评估几个人口统计学和人体测量学参数[年龄，体重，身高，体重指数，体表面积（BSA）]对rhTSH给药后血清TSH峰值水平的影响。rhTSH给药112例分化型甲状腺癌患者根据传统的两个剂量方案（0.9 mg/d）。分别于第1次rhTSH给药前、后24 h及第2次rhTSH给药后24、48、72 h测定血清TSH水平，其中1例重度肥胖患者血清TSH峰值未达到有效刺激范围。血清TSH峰值水平与体重（r = -0.69; P < 0.0001）、体重指数（r = -0.51; P < 0.0001）和BSA（r = -0.72; P < 0.0001）呈负相关。在包括人口统计学和人体测量学变量的多变量回归分析中，只有BSA与血清TSH峰值浓度独立相关（标准化β系数= -0.721; P < 0.0001）。未来的研究应评估使用个性化rhTSH剂量的可能性，根据BSA进行调整。
Recombinant human TSH (rhTSH) has been proposed as an alternative method to the withdrawal of thyroid hormones in the follow-up of differentiated thyroid cancer. The aim of the present study was to evaluate the influence of several demographic and anthropometric parameters [age, body weight, height, body mass index, and body surface area (BSA)] on serum peak TSH levels after rhTSH administration.rhTSH was administered to 112 patients with differentiated thyroid carcinoma according to the conventional two-dose schedule (0.9 mg/d). Serum TSH levels were measured 24 h before and after the first administration of rhTSH, and then 24, 48, and 72 h after the second administration of rhTSH.In one severely obese patient, serum peak TSH values did not reach a valid stimulation range. Serum peak TSH levels were negatively related to body weight (r = -0.69; P < 0.0001), body mass index (r = -0.51; P < 0.0001), and BSA (r = -0.72; P < 0.0001). In a multivariate regression analysis including demographic and anthropometric variables, only BSA was independently associated to serum peak TSH concentrations (standardized beta coefficient = -0.721; P < 0.0001).In conclusion, body size seems to influence serum peak TSH levels after rhTSH administration. Future studies should evaluate the possibility of using personalized rhTSH doses, adjusted in relation to BSA.