A sensitive gait parameter for quantification of arthritis in rats
A sensitive gait parameter for quantification of arthritis in rats
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DOI：
10.1254/jphs.sc0060156
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发表时间：
2007-01-01
影响因子：
3.5
通讯作者：
Matsuda, Hiroshi
中科院分区：
文献类型：
--
作者：
Orito, Kensuke;Kurozumi, Shogo;Matsuda, Hiroshi
关节炎的量化有助于研究关节炎的疼痛机制和开发新的药物。我们评估并确定了一个可行的参数，量化大鼠关节炎使用一种新的步态分析系统。膝关节注射小剂量的葡聚糖-角叉菜胶以剂量依赖性方式降低摆动时间比（STR，未处理后肢的摆动时间/注射A-角叉菜胶后肢的摆动时间）。腹腔注射吲哚美辛可剂量依赖性地恢复减少的STR。关节炎不能准确地量化摆动时间和肿胀，关节炎的常见指标。这些结果表明，STR是一个敏感的，可靠的参数量化关节炎。
Quantification of arthritis is helpful for investigating pain mechanisms of arthritis and for developing new drugs. We assessed and identified a feasible parameter for quantification of rat arthritis using a novel gait analyzing system. Knee-joint injection with small doses of lambda-carrageenan decreased swing time ratio (STR, swing time of the non-treated hindlimb/swing time of the A-carrageenan-injected hindlimb) in a dose-dependent manner. Intraperitoneal treatment with indomethacin restored the decreased STR dose-dependently. The arthritis could not be accurately quantified by swing time and swelling, common indices of arthritis. These results show that STR is a sensitive, reliable parameter for quantification of arthritis.