Predictive value of decreased p27Kip1 protein expression for the recurrence-free and long-term survival of prostate cancer patients.
Predictive value of decreased p27Kip1 protein expression for the recurrence-free and long-term survival of prostate cancer patients.
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DOI：
10.1038/sj.bjc.6690806
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发表时间：
1999-11
影响因子：
8.8
通讯作者：
Serth J
中科院分区：
文献类型：
--
作者：
Kuczyk M;Machtens S;Hradil K;Schubach J;Christian W;Knüchel R;Hartmann J;Bokemeyer C;Jonas U;Serth J
p27 Kip 1基因被鉴定为细胞周期阻滞在G1检查点的诱导物，以防止当发生大量DNA损伤时体细胞进入细胞周期的S期。已经表明，p27 Kip 1蛋白表达的降低可能有助于人类恶性肿瘤的发展，由于关键的抗增殖机制的丧失。在本研究中，从汉诺威大学泌尿外科接受根治性尿道切除术的95例患者中随机选择95例标本（T1-T4），（82名患者）以及里根斯堡的约瑟夫医院（13例患者）在1981年和1992年之间，可获得用于免疫组织化学研究的组织块，研究了不同的生物学和临床特征作为无复发和长期生存的可能预测因素：年龄、肿瘤浸润深度、组织学分级、淋巴结状态以及p27 Kip 1蛋白表达降低。在中位随访56个月后，（24-151个月），21例p27 Kip 1蛋白表达缺失或阳性染色肿瘤细胞相对量<10%的患者中有7例（33%）（第1组）复发，而74例p27 Kip 1蛋白表达保留的患者中有17例（23%）（第2组（≥10%的阳性染色肿瘤细胞）。第1组患者的中位无复发生存期为14个月（5-40个月），第2组患者的中位无复发生存期为31个月（7-133个月）（P = 0.02）。在多变量分析中，p27 Kip 1蛋白表达的缺失被确定为无复发生存的唯一独立预后参数。与此相反，无论是单变量还是多变量分析均未显示p27 Kip 1蛋白表达缺失与患者长期生存之间的相关性。迫切需要前瞻性研究来证实p27 Kip 1蛋白表达降低与p53肿瘤抑制蛋白过度表达在局限性前列腺癌患者中的独立预后价值。除了已确定的预后因素（如肿瘤分期或Gleason评分）外，更精确的临床重要生物学变量的可用性可能有助于局部复发或全身肿瘤进展高风险患者的决策。© 1999癌症研究运动
The p27Kip1 gene has been identified as inductor of cell cycle arrest at the G1 checkpoint to prevent entry of somatic cells into the S phase of the cell cycle when substantial DNA damage has occurred. It has been suggested that decreased expression of the p27Kip1 protein may contribute to the development of human malignancies due to loss of critical antiproliferative mechanisms. In the present study, 95 specimens (T1–T4) from 95 randomly selected patients undergoing radical prostatectomy at the Urological Department of Hannover University (82 patients) as well as in the Josef Hospital Regensburg (13 patients) between 1981 and 1992 for whom tissue blocks for immunohistochemical investigation were available, were investigated for different biological and clinical characteristics as possible predictors for recurrence-free and long-term survival: age, depth of tumour infiltration, histological grade, lymph node status, as well as decreased expression of the p27Kip1 protein. After a median follow-up up of 56 months (24–151 months), seven of 21 (33%) patients (Group 1) with loss of p27Kip1 protein expression or a relative amount of <10% of positively stained tumour cells developed recurrent disease in contrast to 17 of 74 (23%) patients (Group 2) with retained p27Kip1 protein expression (≥10% of positively stained tumour cells). The median recurrence-free survival was 14 months (5–40 months) for patients from Group 1 and 31 months (7–133 months) for Group 2 patients (P = 0.02). In multivariate analysis, loss of p27Kip1 protein expression was identified as the only independent prognostic parameter for recurrence-free survival. In contrast, neither the univariate nor the multivariate analysis showed a correlation between loss of p27Kip1 protein expression and the long-term survival of the patients. Prospective studies are urgently needed to confirm the independent prognostic value of decreased p27Kip1 protein expression together with overexpression of the p53 tumour suppressor protein in patients with localized prostate cancer. The availability of more refined prognostically important biological variables in addition to established prognostic factors like tumour stage or Gleason score might help decision making in patients at high risk for the development of local recurrence or systemic tumour progression. © 1999 Cancer Research Campaign
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影响因子：
10.5
作者：
POLYAK, K;KATO, JY;KOFF, A
通讯作者：
KOFF, A
影响因子：
64.5
作者：
KATO, JY;MATSUOKA, M;SHERR, CJ
通讯作者：
SHERR, CJ
DOI：
10.1093/jnci/90.12.916
发表时间：
1998-06-17
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Cote, RJ;Shi, Y;Lieskovosky, G
通讯作者：
Lieskovosky, G
影响因子：
8
作者：
Craig, C;Wersto, R;Seth, P
通讯作者：
Seth, P
影响因子：
6.2
作者：
COFFEY, DS
通讯作者：
COFFEY, DS