Non-melanoma skin cancer
Non-melanoma skin cancer
复制标题
DOI：
10.1016/s0140-6736(09)61196-x
复制
发表时间：
2010-02-20
期刊：
影响因子：
168.9
通讯作者：
Szeimies, Rolf-Markus
中科院分区：
文献类型：
--
作者：
Madan, Vishal;Lear, John T.;Szeimies, Rolf-Markus
非黑色素瘤皮肤癌的发病率和发病率的不断上升，引起了人们对其发病机制的研究和寻找新的非侵入性治疗方法的极大兴趣。尽管累积的阳光照射在鳞状细胞癌发病机制中的作用似乎很清楚，但阳光照射模式与基底细胞癌亚型之间的关系仍不确定。几个复杂的基因型，表型和环境因素有助于非黑色素瘤皮肤癌的发病机制。与基底细胞癌不同，鳞状细胞癌可由前驱病变引起。非黑色素瘤皮肤癌的诊断在临床上进行，并通过组织学检查证实。预后取决于病变和宿主的特征，这也决定了治疗的选择。预防策略旨在减少阳光照射，但尚未证实其益处，特别是对基底细胞癌。鳞状细胞癌和大多数基底细胞癌的主要治疗方法是切除预定的边缘。在新的非侵入性治疗中，只有光动力疗法和局部咪喹莫特已成为基底细胞癌特定亚型的既定治疗方法，并且仍在继续寻找更有效的组织挽救疗法。
The rising incidence and morbidity of non-melanoma skin cancers has generated great interest in untravelling of their pathogenesis and in the search for new non-invasive treatments. Whereas the role of cumulative sun exposure in pathogenesis of squamous-cell carcinoma seems clear, the relation between sun-exposure patterns and subtypes of basal-cell carcinoma remains undetermined. Several complex genotypic, phenotypic, and environmental factors contribute to pathogenesis of non-melanoma skin cancers. Unlike basal-cell carcinoma, squamous-cell carcinomas can arise from precursor lesions. Diagnosis of non-melanoma skin cancer is made clinically and confirmed by histological testing. Prognosis depends on lesion and host characteristics, which also dictate choice of treatment. Prevention strategies aim at reduction of sun exposure, but are of unproven benefit, especially for basal-cell carcinoma. Surgical excision with predetermined margins is the mainstay of treatment for squamous-cell carcinoma and for most basal-cell carcinomas. Of the new non-invasive treatments, only photodynamic therapy and topical imiquimod have become established treatments for specific subtypes of basal-cell carcinoma, and the search for more effective and tissue-salvaging therapies continues.