Sod2 knockdown in the musculature has whole-organism consequences in Drosophila.
Sod2 knockdown in the musculature has whole-organism consequences in Drosophila.
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DOI：
10.1016/j.freeradbiomed.2009.06.021
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发表时间：
2009-09-15
影响因子：
7.4
通讯作者：
Grotewiel, Mike
中科院分区：
文献类型：
--
作者：
Martin, Ian;Jones, Melanie A.;Rhodenizer, Devin;Zheng, Jie;Warrick, John M.;Seroude, Laurent;Grotewiel, Mike
Oxidative damage to cell macromolecules by reactive oxygen species is associated with numerous diseases and aging. In Drosophila, RNAi-mediated silencing of the mitochondrial antioxidant manganese superoxide dismutase (SOD2) throughout the body dramatically reduces life span, accelerates senescence of locomotor function, and enhances sensitivity to applied oxidative stress. Here, we show that Sod2 knock-down in the musculature alone is sufficient to cause the shortened life span and accelerated locomotor declines observed with knock-down of Sod2 throughout the body, indicating that Sod2 deficiency in muscle is central to these phenotypes. Knock-down of Sod2 in the muscle also increased caspase activity (a marker for apoptosis) and caused a mitochondrial pathology characterized by swollen mitochondria, decreased mitochondrial content and reduced ATP levels. These findings indicate that Sod2 plays a crucial role in the musculature in Drosophila and that the consequences of Sod2 loss in this tissue extend to the viability of the organism as a whole.
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影响因子：
4.4
作者：
Justilien, Verline;Pang, Ji-Jing;Lewin, Alfred S.
通讯作者：
Lewin, Alfred S.
影响因子：
9.8
作者：
Fayyazuddin A;Zaheer MA;Hiesinger PR;Bellen HJ
通讯作者：
Bellen HJ
影响因子：
3.5
作者：
Lievens, Jean-Charles;Iche, Magali;Birman, Serge
通讯作者：
Birman, Serge
影响因子：
9.2
作者：
Kapahi, P;Zid, BM;Benzer, S
通讯作者：
Benzer, S
DOI：
10.1073/pnas.252342899
发表时间：
2002-12-10
影响因子：
11.1
作者：
Kirby, K;Hu, JG;Phillips, JP
通讯作者：
Phillips, JP