Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants
Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants
复制标题
DOI：
10.1016/s0264-410x(00)00008-6
复制
发表时间：
2000-05-08
期刊：
影响因子：
5.5
通讯作者：
Daynes, RA
中科院分区：
文献类型：
--
作者：
Enioutina, EY;Visic, DM;Daynes, RA
以霍乱毒素作为黏膜佐剂，口服流感嗜血杆菌b型寡糖结合白喉CRM197蛋白（Hib-DT）疫苗免疫老年小鼠，可抑制普通黏膜免疫应答。用含有Hib-DT和1 α，25-二羟基维生素D-3 (1,25（OH)(2)D-3）的疫苗配方皮下免疫的老年小鼠，普通粘膜和全身体液免疫反应也受到抑制。通过口服和皮下免疫途径，在老年小鼠的饮食中补充抗氧化维生素E或已知的过氧化物酶体增殖物激活受体(ppar - α) α异构体的激活剂，能够将它们的粘膜和全身体液免疫应答恢复到成熟成人的水平。这些数据支持一种假设，即免疫衰老的某些方面是由于细胞功能失调，而不是由于免疫系统细胞成分的任何不可逆转的缺陷。(C) 2000 Elsevier Science Ltd.版权所有。
Common mucosal immune responses were depressed in aged mice that were orally immunized with Haemophilus influenzae type b oligosaccharide conjugated to Diphtheria CRM197 protein (Hib-DT) vaccine using cholera toxin as the mucosal adjuvant. Both common mucosal and systemic humoral immune responses were also depressed in aged mice that were subcutaneously immunized with vaccine formulations containing Hib-DT plus 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3). Dietary supplementation of aged mice with either the antioxidant vitamin E, or with known activators of the alpha isoform of the peroxisome proliferator activated receptor (PPAR-alpha) was capable of restoring their mucosal and systemic humoral immune responses to mature adult levels, by both the oral and subcutaneous routes of immunization. These data support a hypothesis that some aspects of immunosenescence are due to dysregulations in cellular functions, and are not due to any irreversible defects in cellular components of the immune system. (C) 2000 Elsevier Science Ltd. All rights reserved.