Novel biochemical pathways in parasitic protozoa
Novel biochemical pathways in parasitic protozoa
复制标题
寄生原生动物的新生化途径
作者：
A. Fairlamb
在整个进化过程中，酶及其代谢物一直高度保守。寄生虫也不例外，最显著的区别是缺乏哺乳动物宿主的代谢途径。一般来说，寄生虫代谢迟缓，依靠宿主的代谢来供应嘌呤、脂肪酸、甾醇和氨基酸等预制成分，并清除最终产物。尽管如此，寄生虫的代谢非常复杂，因为(1)它们保留了在需要时诱导许多途径的遗传能力，(2)它们在宿主中发展了复杂的生存机制。将讨论锥虫、利什曼原虫、疟疾和厌氧原生动物代谢的某些独特特征。这将包括(1)糖酵解和电子传递，参考独特的细胞器：糖体和氢酶体，(2)嘌呤回收，嘧啶生物合成和叶酸代谢，(3)多胺和硫醇代谢，特别参考锥虫和利什曼原虫独特的代谢物，锥虫硫酮的作用。
SUMMARY Throughout evolution, enzymes and their metabolites have been highly conserved. Parasites are no exception to this and differ most markedly by the absence of metabolic pathways that are present in the mammalian host. In general, parasites are metabolically lazy and rely on the metabolism of the host both for a supply of prefabricated components such as purines, fatty acids, sterols and amino acids and for the removal of end-products. Nonetheless, parasites are metabolically highly sophisticated in that (1) they retain the genetic capacity to induce many pathways, when needed, and (2) they have developed complex mechanisms for their survival in the host. Certain unique features of the metabolism of trypanosomes, leishmania, malaria and anaerobic protozoa will be discussed. This will include (1) glycolysis and electron transport with reference to the unique organelles: the glycosome and the hydrogenosome, (2) purine salvage, pyrimidine biosynthesis and folic acid metabolism and (3) polyamine and thiol metabolism with special reference to the role of the unique metabolite of trypanosomes and leishmanias, trypanothione.
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DOI：
10.1073/pnas.83.8.2584
发表时间：
1986-04
影响因子：
11.1
作者：
S. Beverley;T. Ellenberger;J. S. Cordingley
通讯作者：
S. Beverley;T. Ellenberger;J. S. Cordingley
NADPH：溶组织内阿米巴黄素氧化还原酶的纯化和性质。
影响因子：
1.5
作者：
Lo,H;Reeves,RE
通讯作者：
Reeves,RE
影响因子：
1.5
作者：
Aman,RA;Wang,CC
通讯作者：
Wang,CC
影响因子：
56.9
作者：
ROGERS, S;WELLS, R;RECHSTEINER, M
通讯作者：
RECHSTEINER, M
感染恶性疟原虫疟原虫的红细胞中糖酵解途径的酶。
影响因子：
20.3
作者：
RothJr,EF;Calvin,MC;Max-Audit,I;Rosa,J;Rosa,R
通讯作者：
Rosa,R