High-energy phosphate metabolism in vascular smooth muscle.
High-energy phosphate metabolism in vascular smooth muscle.
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DOI：
10.1146/annurev.ph.47.030185.003213
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发表时间：
1985
影响因子：
18.2
通讯作者：
T. Butler;M. J. Siegman
中科院分区：
文献类型：
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作者：
T. Butler;M. J. Siegman
历史上，对肌肉收缩的能量学研究一直落后于横纹肌。现在很明显，通过使用与应用于横纹肌的技术类似的技术，可以获得关于高能磷酸盐分解在平滑肌中转化为机械输出的机制的重要信息。平滑肌肉和横纹肌的能量代谢在某些方面是相似的，但存在某些主要差异，这与这两种肌肉类型的功能专门化相一致。本章的重点是描述机械输出、高能磷酸盐利用和平滑肌收缩过程中中间代谢之间的关系。
Studies on the energetics of smooth muscle contraction historically have lagged behind those on striated muscle. It is now apparent that through the use of techniques similar to those applied to striated muscle, significant information can be gained concerning the mechanism of transduction of high-energy phosphate breakdown into a mechanical output in smooth muscle. Some aspects of energy metabolism are similar in smooth and striated muscles, but there are certain major differences that are consistent with the functional specialization of the two muscle types. The emphasis of this chapter is to describe the relationships among mechanical output, high-energy phosphate utilization, and intermediary metabolism during smooth muscle contraction.