Partial K-Complex Recovery Following Short-Term Abstinence in Individuals with Alcohol Use Disorder.
Partial K-Complex Recovery Following Short-Term Abstinence in Individuals with Alcohol Use Disorder.
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DOI：
10.1111/acer.12769
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Colrain IM
中科院分区：
文献类型：
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作者：
Willoughby AR;de Zambotti M;Baker FC;Colrain IM
K复合波（KC）是非快速眼动（NREM）睡眠的脑电位特征，由大量神经元的同步活动引起，并被假设为反映大脑的完整性。与年龄匹配的对照组相比，酒精使用障碍（AUD）患者的KC振幅较低，但尚未研究短期戒酒后的恢复情况。因此，我们研究了在AUD患者禁欲的前四个月，KC是否显示出显著的恢复。16名最近戒酒的AUD（46.6 ± 9.3岁）和13名性别和年龄匹配的健康对照（41.6 ± 8.3岁）在三个场合进行了研究：初始阶段是在AUD最后一次饮酒的1个月内，然后是1个月和3个月后。在第2阶段NREM睡眠期间，记录参与者的夜间脑电图（EEG），同时向参与者呈现音调以引起KC。在初始阶段，AUD显示与对照组相比显著较低的KC振幅和发生率。在AUD个体中，KC振幅从初始到1个月会话显著增加。KC发病率略有显著增加。从1个月到3个月，KC振幅和发生率均未发生变化。在对照组中未观察到KC振幅或发生率的变化。我们的研究结果表明，部分KC恢复在前两个月的禁欲。这种恢复与最近的神经影像学结果表明的戒断AUD中结构性脑恢复的时间过程一致。
The K-complex (KC) is a brain potential characteristic of non-rapid eye movement (NREM) sleep resulting from the synchronous activity of a large population of neurons and hypothesized to reflect brain integrity. KC amplitude is lower in individuals with Alcohol Use Disorder (AUD) compared with age-matched controls but its recovery with short-term abstinence has not been studied. Therefore, we investigated whether the KC shows significant recovery over the first four months of abstinence in individuals with AUD. 16 recently abstinent AUD (46.6 ± 9.3 years) and 13 gender and age-matched healthy controls (41.6 ± 8.3 years) were studied on three occasions: the Initial session was within 1 month of the AUD last drink, then 1 month and 3 months later. Overnight electroencephalogram (EEG) was recorded while participants were presented with tones during stage 2 NREM sleep to elicit KCs. At the Initial session, AUD showed significantly lower KC amplitude and incidence compared with controls. In the AUD individuals, KC amplitude increased significantly from the Initial to the 1 month session. KC incidence showed a marginally significant increase. Neither KC amplitude nor incidence changed from the 1 month to the 3 month session. No changes in KC amplitude or incidence across sessions were observed in the control group. Our results demonstrate partial KC recovery during the first two months of abstinence. This recovery is consistent with the time course of structural brain recovery in abstinent AUD demonstrated by recent neuroimaging results.