Expression of insulin-like growth factor-2 can predict the prognosis of human colorectal cancer patients: Correlation with tumor progression, proliferative activity and survival
Expression of insulin-like growth factor-2 can predict the prognosis of human colorectal cancer patients: Correlation with tumor progression, proliferative activity and survival
复制标题
DOI：
10.1159/000011858
复制
发表时间：
1998-05-01
期刊：
影响因子：
3.5
通讯作者：
Imamura, M
中科院分区：
文献类型：
--
作者：
Kawamoto, K;Onodera, H;Imamura, M
胰岛素样生长因子-2（IGF-2）在人结直肠癌组织标本和细胞系中的表达已有报道。然而，IGF-2在结直肠癌患者中的作用尚不清楚。本研究对92例结直肠癌患者的组织样本进行IGF-2染色，并分析IGF-2染色与临床病理变量、增殖细胞核抗原（PCNA）染色和患者生存期的关系。IGF-2染色与肿瘤进展、PCNA染色和患者生存相关。我们的研究结果表明，IGF-2在肿瘤进展中起着重要作用，IGF-2染色是有用的结直肠癌患者的预后因素。
Expression of insulin-like growth factor-2 (IGF-2) has been reported in tissue specimens and cell lines of human colorectal cancers. However, the effects of IGF-2 in colorectal cancer patients are not well known. In this study, IGF-2 staining was performed on tissue samples from 92 patients with colorectal cancer, and the relationship of IGF-2 staining to clinicopathological variables, proliferating cell nuclear antigen (PCNA) staining and patient survival was analyzed. IGF-2 staining was correlated with tumor progression, PCNA staining and patient survival. Our results suggest that IGF-2 plays an important role in tumor progression and that IGF-2 staining is useful as a prognostic factor in colorectal cancer patients.