Tuberculosis associates with both airflow obstruction and low lung function: BOLD results.
Tuberculosis associates with both airflow obstruction and low lung function: BOLD results.
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DOI：
10.1183/13993003.02325-2014
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
BOLD Collaborative Research Group
中科院分区：
文献类型：
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作者：
Amaral AF;Coton S;Kato B;Tan WC;Studnicka M;Janson C;Gislason T;Mannino D;Bateman ED;Buist S;Burney PG;BOLD Collaborative Research Group
在小型研究和病例系列中，肺结核病史既与慢性阻塞性肺疾病的特征气流阻塞有关，也与肺活量测定的限制性模式有关。评估肺结核病史与成人气流阻塞和肺活量异常之间的关系。这项研究是在40岁及以上的成年人中进行的，他们参加了多中心横断面、一般人群为基础的阻塞性肺疾病负担研究，提供了可接受的支气管扩张剂后肺活量测量和关于肺结核病史的信息。在每个参与中心内评估肺结核病史与气流阻塞和肺活量限制之间的关系，并使用荟萃分析结合评估。根据国民总收入，这些估计数按高收入国家和低收入国家/中等收入国家分层。自我报告的肺结核病史与气流阻塞(调整后的优势比=2.51，95%可信区间1.83-3.42)和肺活量受限(调整后的优势比=2.13，95%可信区间1.42-3.19)相关。肺结核病史与气流阻塞和肺活量限制有关，应该被认为是阻塞性疾病和低肺功能的潜在重要原因，特别是在结核病常见的地方。
In small studies and cases series, a history of tuberculosis has been associated with both airflow obstruction, which is characteristic of chronic obstructive pulmonary disease, and restrictive patterns on spirometry. To assess the association between a history of tuberculosis and airflow obstruction and spirometric abnormalities in adults. The study was performed in adults, aged 40 and above, who took part in the multicentre cross-sectional, general population-based, Burden of Obstructive Lung Disease study, had provided acceptable post-bronchodilator spirometry measurements and information on a history of tuberculosis. The associations between a history of tuberculosis and airflow obstruction and spirometric restriction were assessed within each participating centre, and estimates combined using meta-analysis. These estimates were stratified by high and low/middle income countries, according to gross national income. A self-reported history of tuberculosis was associated with airflow obstruction (adjusted odds ratio = 2.51, 95% confidence interval 1.83-3.42) and spirometric restriction (adjusted odds ratio = 2.13, 95% confidence interval 1.42-3.19). A history of tuberculosis was associated with both airflow obstruction and spirometric restriction, and should be considered as a potentially important cause of obstructive disease and low lung function, particularly where tuberculosis is common.