Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders.
Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders.
复制标题
DOI：
10.3389/fcimb.2022.1059825
复制
发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
每年，数以百万计的妇女受到生殖道疾病的影响，如细菌性阴道病(BV)、子宫内膜癌、多囊卵巢综合征(PCOS)、子宫内膜异位症和子宫肌瘤(UF)。这些疾病对医疗保健系统造成了巨大的经济负担，并对健康和生育结果产生了严重影响。该综述探讨了肠道、阴道和子宫的生物失调与女性生殖道各种疾病的发病机制之间的关系。近年来，生殖健康临床医生和科学家将注意力集中在微生物组上，以研究其在此类疾病的发病机制和预防中的作用。最近对肠道、阴道和子宫微生物群的研究发现，与特定的健康和疾病状态有关的细菌组成和个体生活中的变化模式，特别是关于雌激素-肠道微生物群轴对雌激素驱动的疾病(如子宫内膜癌、子宫内膜异位症和UF)和与雌激素缺乏相关的疾病(如PCOS)的影响。此外，该综述还讨论了维生素D缺乏对肠道生物失调和雌激素代谢改变的贡献，以及这些变化如何在UF的发病机制中发挥关键作用。更多关于微生物群对生殖健康和生育的影响的研究是至关重要的。
Every year, millions of women are affected by genital tract disorders, such as bacterial vaginosis (BV), endometrial cancer, polycystic ovary syndrome (PCOS), endometriosis, and uterine fibroids (UFs). These disorders pose a significant economic burden on healthcare systems and have serious implications for health and fertility outcomes. This review explores the relationships between gut, vaginal, and uterine dysbiosis and the pathogenesis of various diseases of the female genital tract. In recent years, reproductive health clinicians and scientists have focused on the microbiome to investigate its role in the pathogenesis and prevention of such diseases. Recent studies of the gut, vaginal, and uterine microbiomes have identified patterns in bacterial composition and changes across individuals’ lives associated with specific healthy and diseased states, particularly regarding the effects of the estrogen–gut microbiome axis on estrogen-driven disorders (such as endometrial cancer, endometriosis, and UFs) and disorders associated with estrogen deficiency (such as PCOS). Furthermore, this review discusses the contribution of vitamin D deficiency to gut dysbiosis and altered estrogen metabolism as well as how these changes play key roles in the pathogenesis of UFs. More research on the microbiome influences on reproductive health and fertility is vital.