Molecular mechanism of the chemopreventive effect of resveratrol
Molecular mechanism of the chemopreventive effect of resveratrol
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DOI：
10.1016/s0027-5107(02)00330-5
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发表时间：
2003-02-01
影响因子：
2.3
通讯作者：
Dong, ZG
中科院分区：
文献类型：
--
作者：
Dong, ZG
化学预防是一种很有前途的控制人类癌症的方法。白藜芦醇已被证明在多种致癌模型中具有有效的化学预防作用。然而，其抗癌作用的确切机制尚不清楚。本文综述了近年来本实验室对白藜芦醇作用机制的研究进展。在JB6细胞中，白藜芦醇可诱导细胞凋亡，抑制肿瘤启动子诱导的细胞转化。我们还发现白藜芦醇诱导的p53活化和白藜芦醇诱导的细胞凋亡是通过p53依赖途径发生的。MAP激酶、ERKs、JNKs或p38激酶参与白藜芦醇诱导的p53活化和细胞凋亡。(C) 2002 Elsevier Science b.v.版权所有
Chemoprevention is a promising approach to control human cancer. Resveratrol has been shown to have a potent chemopreventive effect in multiple carcinogenesis models. However, the precise mechanism explaining its anti-carcinogenic effect is not clear. This review summarizes recent studies from our laboratory on the mechanisms of resveratrol's effects. In JB6 cells, resveratrol was found to induce apoptosis and inhibit tumor promoter-induced cell transformation. We also found that resveratrol-induced activation of p53 and resveratrol-induced apoptosis occurred through a p53-dependent pathway. The MAP kinases, ERKs, JNKs, or p38 kinases, are involved in resveratrol-induced activation of p53 and apoptosis. (C) 2002 Elsevier Science B.V All rights reserved.