Oscillatory Activity and Phase-Amplitude Coupling in the Human Medial Frontal Cortex during Decision Making
Oscillatory Activity and Phase-Amplitude Coupling in the Human Medial Frontal Cortex during Decision Making
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DOI：
10.1162/jocn.2008.21020
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发表时间：
2009-02-01
影响因子：
3.2
通讯作者：
Fell, Juergen
中科院分区：
文献类型：
--
作者：
Cohen, Michael X.;Elger, Christian E.;Fell, Juergen
在内侧额叶皮层内部和上方记录的脑电图振荡与一系列认知功能有关，包括正反馈和负反馈处理。在决策过程中的内侧额叶振荡特性仍然在很大程度上未知。在这里，我们研究了人类内侧额叶皮层的振荡活动记录，而受试者玩竞争性决策游戏。在不同的决策相关过程期间观察到多个频带中的功率和交叉试验相位相干性的不同模式（例如，反馈预期与反馈处理）。决策和反馈处理伴随着在220毫秒左右的交叉试验相位相干性的宽带增加，以及功率的动态波动。反馈预期伴随着功率谱从相对较低（δ和θ）到较高（α和β）功率的转变。功率和交叉试验相位相干性在θ、α和β频带中的损失比胜利更大，但在δ频带中的损失比胜利更大。最后，我们发现α和β频段的振荡功率与δ和θ振荡的相位同步（“相位-振幅耦合”）。这种同步在输和赢之间有所不同，这表明相位振幅耦合可能反映了内侧额叶皮质中反馈价编码的机制。我们的研究结果链接内侧额叶振荡的决策，与活动之间的关系，在不同的频带建议相位利用编码的反馈价信息。
Electroencephalogram oscillations recorded both within and over the medial frontal cortex have been linked to a range of cognitive functions, including positive and negative feedback processing. Medial frontal oscillatory characteristics during decision making remain largely unknown. Here, we examined oscillatory activity of the human medial frontal cortex recorded while subjects played a competitive decision-making game. Distinct patterns of power and cross-trial phase coherence in multiple frequency bands were observed during different decision-related processes (e.g., feedback anticipation vs. feedback processing). Decision and feedback processing were accompanied by a broadband increase in cross-trial phase coherence at around 220 msec, and dynamic fluctuations in power. Feedback anticipation was accompanied by a shift in the power spectrum from relatively lower (delta and theta) to higher (alpha and beta) power. Power and cross-trial phase coherence were greater following losses compared to wins in theta, alpha, and beta frequency bands, but were greater following wins compared to losses in the delta band. Finally, we found that oscillation power in alpha and beta frequency bands were synchronized with the phase of delta and theta oscillations ("phase-amplitude coupling''). This synchronization differed between losses and wins, suggesting that phase amplitude coupling might reflect a mechanism of feedback valence coding in the medial frontal cortex. Our findings link medial frontal oscillations to decision making, with relations among activity in different frequency bands suggesting a phase-utilizing coding of feedback valence information.