Preparation of polyacrylamide based microgels with different charges for drug encapsulation
Preparation of polyacrylamide based microgels with different charges for drug encapsulation
复制标题
不同电荷聚丙烯酰胺基药物微凝胶的制备
DOI：
10.1016/j.eurpolymj.2013.04.003
复制
发表时间：
2013
影响因子：
6
通讯作者：
G. Rempel
中科院分区：
文献类型：
--
作者：
Hui Wang;Youssef Helwa;G. Rempel
水凝胶独特的物理化学性质在药物储存和释放方面的应用引起了人们的广泛关注。本文中，通过反相乳液聚合方法制备了一系列在不同pH（1、7和13）下具有不同电荷（阳离子、中性和阴离子）的基于丙烯酰胺的水凝胶。研究了pH值和水相与有机相（w/o）比对所产生的水凝胶的尺寸的影响。使用黄绿素作为模型药物来评估和优化水凝胶的包封效率。通过光学显微镜和共聚焦荧光显微镜观察了凝胶中荧光素的存在和分布。结果发现，在pH = 13时，水凝胶溶胀到最大程度，并且它们的尺寸随着w/o比的减小而增大。在pH = 13时，黄绿素分子分散在阳离子和阴离子水凝胶中，包封率为45wt%。这项研究提供了一种制备具有所需性质的水凝胶的便捷方法，并展示了使用水凝胶储存和稳定治疗药物的潜力。
The unique physicochemical properties of hydrogels have attracted considerable attention in their drug storage and delivery applications. Herein, a series of acrylamide based hydrogels with different charges (cationic, neutral, and anionic) under different pH (1, 7, and 13) were prepared via an inverse emulsion polymerization process. The effects of pH and aqueous to organic phase (w/o) ratio on the size of the produced hydrogels were studied. Fluorescein was used as the model drug to assess and optimize the encapsulation efficiency of the hydrogels. Optical microscopy and confocal fluorescence microscopy were carried out to examine the existence and distribution of fluorescein inside the hydrogels. It was found that the hydrogels were swollen to the greatest extent at pH=13 and their size increased with decreasing w/o ratio. Fluorescein was molecularly dispersed within the cationic and anionic hydrogels at pH=13 with an encapsulation efficiency of ∼45wt%. This study provides a convenient method to prepare hydrogels with the required properties and demonstrates the potential of using hydrogels to store and stabilize therapeutics.
影响因子：
62.1
作者：
Liu, Juewen;Cao, Zehui;Lu, Yi
通讯作者：
Lu, Yi
影响因子：
6.2
作者：
Delgado, M;Spanka, C;Janda, KD
通讯作者：
Janda, KD
影响因子：
14
作者：
Yun, YH;Goetz, DJ;Chen, WL
通讯作者：
Chen, WL