Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging.
Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging.
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DOI：
10.31887/dcns.2013.15.1/bluber
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发表时间：
2013-03
影响因子：
8.3
通讯作者：
Lisanby SH
中科院分区：
文献类型：
--
作者：
Luber B;McClintock SM;Lisanby SH
经颅磁刺激（TMS）可用于探测皮质功能和治疗神经精神疾病。经颅磁刺激已经证明了类似于长时程增强和长时程抑郁的神经可塑性作用，并且正在开发用于中风后恢复、阿尔茨海默病和老年人抑郁症的治疗应用。在这里，我们讨论了TMS研究的两个新方向有关的大脑老化和认知。首先，我们介绍了一个范例，提高认知储备，根据我们的研究，睡眠剥夺。其次，我们讨论了磁癫痫发作治疗（MST）的使用，相对于传统的电休克治疗，以备用认知功能，并作为一种手段，提供一个更有效的抗抑郁治疗时，亚惊厥TMS已显示出适度的疗效在老年人。无论是以增强认知为治疗目标，还是以减少健忘症为副作用，这些使用TMS和MST的方法都值得进一步探索其临床潜力。
Transcranial magnetic stimulation (TMS) can be used to probe cortical function and treat neuropsychiatric illnesses. TMS has demonstrated neuroplastic effects akin to long-term potentiation and long-term depression, and therapeutic applications are in development for post-stroke recovery, Alzheimer's disease, and depression in seniors. Here, we discuss two new directions of TMS research relevant to cerebral aging and cognition. First, we introduce a paradigm for enhancing cognitive reserve, based on our research in sleep deprivation. Second, we discuss the use of magnetic seizure therapy (MST) to spare cognitive functions relative to conventional electroconvulsive therapy, and as a means of providing a more potent antidepressant treatment when subconvulsive TMS has shown modest efficacy in seniors. Whether in the enhancement of cognition as a treatment goal, or in the reduction of amnesia as a side effect, these approaches to the use of TMS and MST merit further exploration regarding their clinical potential.