Cytotoxicity and genotoxicity of lipid-oxidation products. Discussion
Cytotoxicity and genotoxicity of lipid-oxidation products. Discussion
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脂质氧化产物的细胞毒性和遗传毒性。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
D. Horrobin
中科院分区：
文献类型：
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作者：
H. Esterbauer;F. Muskiet;D. Horrobin
油、脂肪和食品中所含的不饱和脂质的自氧化以及脂质过氧化引起的膜脂质的内源性氧化降解导致脂质氢过氧化物、链断裂产物和聚合物材料的非常复杂的混合物的形成。实验动物研究和生物化学调查支持这一假设，即与食物一起摄入或内源性产生的脂质氧化产物代表着健康风险。氧化脂质的口服毒性出乎意料地低
The autoxidation of unsaturated lipids contained in oils, fats, and food and the endogenous oxidative degradation of membrane lipids by lipid peroxidation result in the formation of a very complex mixture of lipid hydroperoxides, chain-cleavage products, and polymeric material. Experimental animal studies and biochemical investigations lend support to the hypothesis that lipid-oxidation products, ingested with food or produced endogenously, represent a health risk. The oral toxicity of oxidized lipids is unexpectedly low