Task-specificity in focal dystonia is shaped by aberrant diversity of a functional network kernel
Task-specificity in focal dystonia is shaped by aberrant diversity of a functional network kernel
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DOI：
10.1002/mds.97
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发表时间：
2018-12-01
影响因子：
8.6
通讯作者：
Simonyan, Kristina
中科院分区：
文献类型：
--
作者：
Fuertinger, Stefan;Simonyan, Kristina
目的任务特异性局灶性肌张力障碍选择性地影响熟练和高度学习行为的运动控制。最近的数据表明，神经网络异常的病理生理性肌张力障碍级联反应的发展中的作用。方法我们使用静息态功能性MRI和植根于网络科学和图论的分析技术来检查高度影响脑区域的异常子网络的形成，功能网络内核，以及其对受影响身体区域和熟练运动行为的异常张力障碍连接的影响。结果发现感觉运动皮层和前额叶丘脑在肌张力障碍网络内核的异常嵌入是任务特异性局灶性肌张力障碍的标志。依赖于受影响的身体区域，异常的功能专业化的网络内核包括运动控制管理局灶性手肌张力障碍（作家的抽筋，音乐家的局灶性手肌张力障碍）和感觉运动处理喉肌张力障碍（痉挛性发声障碍，歌手的喉肌张力障碍）的区域。依赖于熟练的运动行为，网络内核的特点是音乐家的肌张力障碍（音乐家的局灶性手肌张力障碍，歌手的喉肌张力障碍）和非音乐家的肌张力障碍（书写痉挛，痉挛性发声障碍）的运动规划和执行电路的感觉反馈异常整合的感觉和运动执行电路之间的连接改变。结论：我们的研究确定了大规模神经连接紊乱的特定特征，这些特征是任务特异性局灶性肌张力障碍的共同病理生理学基础，同时反映了其不同形式的独特病理学。识别影响肌张力障碍网络活动的信息传递的专门区域是未来描绘神经调节靶点作为任务特异性局灶性肌张力障碍的潜在治疗选择的重要一步。(c)2018国际帕金森和运动障碍协会
Objectives Task-specific focal dystonia selectively affects the motor control during skilled and highly learned behaviors. Recent data suggest the role of neural network abnormalities in the development of the pathophysiological dystonic cascade. Methods We used resting-state functional MRI and analytic techniques rooted in network science and graph theory to examine the formation of abnormal subnetwork of highly influential brain regions, the functional network kernel, and its influence on aberrant dystonic connectivity specific to affected body region and skilled motor behavior. Results We found abnormal embedding of sensorimotor cortex and prefrontal thalamus in dystonic network kernel as a hallmark of task-specific focal dystonia. Dependent on the affected body region, aberrant functional specialization of the network kernel included regions of motor control management in focal hand dystonia (writer's cramp, musician's focal hand dystonia) and sensorimotor processing in laryngeal dystonia (spasmodic dysphonia, singer's laryngeal dystonia). Dependent on skilled motor behavior, the network kernel featured altered connectivity between sensory and motor execution circuits in musician's dystonia (musician's focal hand dystonia, singer's laryngeal dystonia) and abnormal integration of sensory feedback into motor planning and executive circuits in non-musician's dystonia (writer's cramp, spasmodic dysphonia). Conclusions Our study identified specific traits in disorganization of large-scale neural connectivity that underlie the common pathophysiology of task-specific focal dystonia while reflecting distinct symptomatology of its different forms. Identification of specialized regions of information transfer that influence dystonic network activity is an important step for future delineation of targets for neuromodulation as a potential therapeutic option of task-specific focal dystonia. (c) 2018 International Parkinson and Movement Disorder Society