Thiazole Orange derivatives: Synthesis, fluorescence properties, and labeling cancer cells
Thiazole Orange derivatives: Synthesis, fluorescence properties, and labeling cancer cells
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噻唑橙衍生物：合成、荧光特性和标记癌细胞
DOI：
10.1016/j.bmc.2008.11.083
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发表时间：
2009-01-15
影响因子：
3.5
通讯作者：
Zhang, Baolian
中科院分区：
文献类型：
--
作者：
Fei, Xuening;Gu, Yingchun;Zhang, Baolian
合成了一系列噻唑橙子（TO）衍生物，并通过在苯并噻唑和4-甲基喹啉上引入不同的取代基对其进行了修饰。所有TO衍生物的结构均经核磁共振氢谱（HNMR）-H-1和质谱确证。TO衍生物的荧光光谱和标记的乳腺癌细胞的显微照片显示了荧光增强现象。这为利用包埋染料标记细胞提供了一种新的尝试。(C)2008爱思唯尔有限公司保留所有权利。
A series of Thiazole Orange (TO) derivatives were synthesized and modified by introducing different substitutional groups on benzothiazole and 4-methylquinoline All the TO derivatives were confirmed by (HNMR)-H-1 and MS. TO derivative bearing NH2- was modified by folic acid and used to label breast cancer cells. The phenomenon of fluorescence enhancement was shown by the fluorescence spectrums of TO derivatives and micrographs of the labeled breast cancer cells. It offered a new try in the aspect of labeling cells by the embedded dyes. (C) 2008 Elsevier Ltd. All rights reserved.