Menstrual physiology: implications for endometrial pathology and beyond.
Menstrual physiology: implications for endometrial pathology and beyond.
复制标题
DOI：
10.1093/humupd/dmv038
复制
发表时间：
2015-11
影响因子：
13.3
通讯作者：
Critchley HO
中科院分区：
文献类型：
--
作者：
Maybin JA;Critchley HO
每月子宫内膜发炎，月经期间子宫腔部分脱落。随后的修复是值得注意的，如果发生受精，就可以进行植入。月经生理异常可导致常见的妇科疾病，如大量或长时间出血。增加对月经生理学过程的了解，可能在其他组织部位也有翻译上的好处。在PubMed和Cochrane数据库中搜索所有英文原创和评论文章，直到2015年4月。搜索词包括“子宫内膜”、“月经”、“子宫内膜修复”、“子宫内膜再生”、“血管生成”、“炎症”和“月经大出血”或“月经过多”。月经在极少数物种中自然发生。人类月经的发生被认为是着床前蜕膜化的结果，赋予胚胎选择性和适应优化功能的能力。我们强调，目前和未来对子宫内膜炎症、血管变化和修复/再生的研究将使我们能够确定常见妇科疾病的新治疗靶点。此外，我们描述了如何增加这种子宫内膜生理学的知识将在其他组织部位有许多翻译应用。我们强调我们所知道的东西的临床应用，仍然存在的关键问题以及未来的科学和医学可能性。对正常和异常情况下的月经进行研究，对于为常见的妇科疾病产生新的、可接受的医疗治疗是必不可少的。此外，与其他领域的专家合作和交流可以显著提高这种动态组织的治疗潜力。
Each month the endometrium becomes inflamed, and the luminal portion is shed during menstruation. The subsequent repair is remarkable, allowing implantation to occur if fertilization takes place. Aberrations in menstrual physiology can lead to common gynaecological conditions, such as heavy or prolonged bleeding. Increased knowledge of the processes involved in menstrual physiology may also have translational benefits at other tissue sites. Pubmed and Cochrane databases were searched for all original and review articles published in English until April 2015. Search terms included ‘endometrium’, ‘menstruation’, ‘endometrial repair’, ‘endometrial regeneration’ ‘angiogenesis’, ‘inflammation’ and ‘heavy menstrual bleeding’ or ‘menorrhagia’. Menstruation occurs naturally in very few species. Human menstruation is thought to occur as a consequence of preimplantation decidualization, conferring embryo selectivity and the ability to adapt to optimize function. We highlight how current and future study of endometrial inflammation, vascular changes and repair/regeneration will allow us to identify new therapeutic targets for common gynaecological disorders. In addition, we describe how increased knowledge of this endometrial physiology will have many translational applications at other tissue sites. We highlight the clinical applications of what we know, the key questions that remain and the scientific and medical possibilities for the future. The study of menstruation, in both normal and abnormal scenarios, is essential for the production of novel, acceptable medical treatments for common gynaecological complaints. Furthermore, collaboration and communication with specialists in other fields could significantly advance the therapeutic potential of this dynamic tissue.