Enantioselective alkylation of β-keto esters by phase-transfer catalysis using chiral quaternary ammonium salts
Enantioselective alkylation of β-keto esters by phase-transfer catalysis using chiral quaternary ammonium salts
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DOI：
10.1021/jo0401772
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发表时间：
2004-10-01
影响因子：
3.6
通讯作者：
Kim, DY
中科院分区：
文献类型：
--
作者：
Park, EJ;Kim, MH;Kim, DY
描述了由辛可宁季铵盐作为相转移催化剂促进的催化对映选择性烷基化。在温和的反应条件下用烷基卤化物处理环β-酮酯，以中等至优异的产率和高对映体过量得到相应的α-烷基化的β-酮酯。
Catalytic enantioselective alkylation promoted by a quaternary ammonium salt from cinchonine as a phase transfer catalyst is described. Treatment of cyclo beta-keto esters with alkyl halide under mild reaction conditions afforded the corresponding alpha-alkylated beta-keto esters in moderate to excellent yields with high enantiomeric excesses.