Long-Term Prognosis of Patients With Takotsubo Syndrome
Long-Term Prognosis of Patients With Takotsubo Syndrome
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DOI：
10.1016/j.jacc.2018.06.016
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发表时间：
2018-08-21
影响因子：
24
通讯作者：
Templin, Christian
中科院分区：
文献类型：
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作者：
Ghadri, Jelena R.;Kato, Ken;Templin, Christian
由于缺乏可用的数据，Takotsubo综合征（TTS）的预后仍然存在争议。此外，触发因素的影响仍然hailing. Acceptives这项研究比较了TTS和急性冠脉综合征（ACS）患者的预后，并调查了TTS的短期和长期结果的基础上不同triggers.METHODS TTS患者从国际Takotsubo注册。将TTS患者的长期死亡率与年龄和性别匹配的ACS患者队列进行比较。此外，短期和长期的结果进行了比较，根据触发conditions.RESULTS总体而言，TTS患者有一个可比的长期死亡风险与ACS患者之间的不同群体。在1,613名TTS患者中，485名患者（30%）检测到情绪触发。在630例（39%）与身体触发因素相关的患者中，98例（6%）患有急性神经系统疾病，而在其他532例（33%）患者中，身体活动、医疗条件或手术是触发条件。其余498例患者（31%）没有可识别的触发因素。TTS患者相关的身体压力表现出更高的死亡率比ACS患者在长期随访，而患者相关的情绪压力有更好的结果相比，ACS patients.CONCLUSIONS总体而言，TTS患者的长期结果相媲美的年龄和性别匹配的ACS患者。此外，我们证明，TTS可以是良性的或危及生命的条件，这取决于煽动压力因素。我们提出了一个新的分类触发器的基础上，它可以作为一个临床工具来预测TTS的短期和长期的结果。(C)2018年由美国心脏病学会基金会。
BACKGROUND Prognosis of Takotsubo syndrome (TTS) remains controversial due to scarcity of available data. Additionally, the effect of the triggering factors remains elusive.OBJECTIVES This study compared prognosis between TTS and acute coronary syndrome (ACS) patients and investigated short- and long-term outcomes in TTS based on different triggers.METHODS Patients with TTS were enrolled from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an age- and sex-matched cohort of patients with ACS. In addition, short- and long-term outcomes were compared between different groups according to triggering conditions.RESULTS Overall, TTS patients had a comparable long-term mortality risk with ACS patients. Of 1,613 TTS patients, an emotional trigger was detected in 485 patients (30%). Of 630 patients (39%) related to physical triggers, 98 patients (6%) had acute neurologic disorders, while in the other 532 patients (33%), physical activities, medical conditions, or procedures were the triggering conditions. The remaining 498 patients (31%) had no identifiable trigger. TTS patients related to physical stress showed higher mortality rates than ACS patients during long-term follow-up, whereas patients related to emotional stress had better outcomes compared with ACS patients.CONCLUSIONS Overall, TTS patients had long-term outcomes comparable to age- and sex-matched ACS patients. Also, we demonstrated that TTS can either be benign or a life-threating condition depending on the inciting stress factor. We propose a new classification based on triggers, which can serve as a clinical tool to predict short- and long-term outcomes of TTS. (C) 2018 by the American College of Cardiology Foundation.